PMID: 9553042May 30, 1998Paper

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

Genes & Development
Andrea I McClatcheyTyler Jacks

Abstract

A role for the membrane/cytoskeleton interface in the development and progression of cancer is established, yet poorly understood. The neurofibromatosis type II (NF2) tumor suppressor gene encodes a member of the ezrin/radixin/moesin (ERM) family of membrane/cytoskeleton linker proteins thought to be important for cell adhesion and motility. We report that in contrast to the narrow spectrum of benign tumors in human NF2 patients, Nf2 heterozygous mice develop a variety of malignant tumors. Using the fact that Nf2 is linked to the p53 tumor suppressor locus in the mouse we have also investigated the effects of genetic linkage of cancer-predisposing mutations on tumorigenesis and examined the genetic pathway to tumor formation involving Nf2 loss. Importantly, we observed a very high rate of metastasis associated with Nf2 deficiency, with or without loss of p53 function, and we provide experimental evidence supporting a role for Nf2 loss in metastatic potential. Together, our results suggest an important role for the NF2 tumor suppressor, and perhaps the ERM family in tumor formation and metastasis.

References

Feb 11, 1966·Science·M P FinkelP B Jinkins
Jan 1, 1994·Current Biology : CB·T JacksR A Weinberg
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R Gary, A Bretscher
Mar 14, 1996·Nature·W F DietrichT J O'Connor
Jul 1, 1996·Genes & Development·M H LeeT Jacks
Jul 18, 1996·Nature·T S HelanderT Timonen
Feb 1, 1996·Current Opinion in Genetics & Development·J F GusellaL B Jacoby
Dec 1, 1995·Cancer Metastasis Reviews·A F ChambersA C Groom
Feb 1, 1997·Trends in Biochemical Sciences·S TsukitaS Tsukita
Mar 1, 1997·Lancet·R Rizzoli, J P Bonjour
May 27, 1997·Neuroreport·J O ClaudioG A Rouleau
Oct 6, 1997·Genes & Development·L Van Aelst, C D'Souza-Schorey
Oct 23, 1997·Current Opinion in Cell Biology·P W KincadeL Hanson
Oct 23, 1997·Current Opinion in Cell Biology·A VaheriO Turunen
Oct 23, 1997·Current Opinion in Cell Biology·S M Frisch, E Ruoslahti

❮ Previous
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Citations

May 26, 1999·The Journal of Pathology·K F Macleod, T Jacks
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Q Islam, K Islam
Dec 14, 2011·Acta Neuropathologica·Steven L Carroll
Mar 21, 2007·Clinical & Experimental Metastasis·Benjamin BruceChand Khanna
Aug 18, 2004·The International Journal of Biochemistry & Cell Biology·Klaus P Hoeflich, Mitsuhiko Ikura
Jul 26, 2005·Mutation Research·Laura D Attardi, Lawrence A Donehower
May 26, 2005·Experimental Cell Research·Petri BonoRichard O Hynes
Sep 5, 2002·Biochemical and Biophysical Research Communications·Jae Young KimYoung-Pil Wang
Feb 27, 2003·Biochemical and Biophysical Research Communications·Jung Yeon LimJoon-ki Kang
Mar 26, 2003·Experimental Cell Research·Alexandra SullivanRick F Thorne
Dec 10, 1999·Survey of Ophthalmology·J W Harbour
May 9, 2001·Biochimica Et Biophysica Acta·A I McClatchey, K Cichowski
May 22, 2002·Biochimica Et Biophysica Acta·Michaela Herzig, Gerhard Christofori
Apr 24, 1999·Biochimica Et Biophysica Acta·J F GusellaL B Jacoby
Dec 22, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·A LochterM J Bissell
Jan 17, 2002·Current Opinion in Cell Biology·Alexis GautreauMonique Arpin
Nov 18, 1998·Current Opinion in Cell Biology·T D Tlsty
Oct 31, 2001·Trends in Cell Biology·L S Sherman, D H Gutmann
Apr 25, 2003·Critical Reviews in Oncology/hematology·Tracey A MartinWen G Jiang
Apr 5, 2001·Trends in Molecular Medicine·N Reed, D H Gutmann
Aug 10, 2007·Nature Reviews. Cancer·Kristopher K Frese, David A Tuveson
Mar 8, 2013·Nature Reviews. Cancer·Kieran F HarveyDavid M Thomas
Mar 15, 2003·Nature Reviews. Cancer·Erik Sahai, Christopher J Marshall
Feb 1, 2007·DNA and Cell Biology·Maya Kansara, David M Thomas
Jul 19, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·J Jason ClarkMarlan R Hansen
Apr 16, 2003·Genes & Development·Dominique LallemandAndrea I McClatchey
Jun 27, 2008·Genes & Development·Bin ZhaoKun-Liang Guan
Aug 3, 2010·Genes & Development·Samira BenhamoucheAndrea I McClatchey
Dec 20, 2012·Genes & Development·Alan M HebertAndrea I McClatchey
Aug 18, 2010·Genes & Development·Chunling Yi, Joseph L Kissil
May 10, 2002·Genes & Development·Michel KalamaridesMarco Giovannini
Dec 11, 1999·Science·K S VogelL F Parada
Nov 4, 2009·Molecular and Cellular Biology·Robert F HenniganWallace Ip
May 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·V P Collins

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