Mice housed on coal dust-contaminated sand: A model to evaluate the impacts of coal mining on health

Toxicology and Applied Pharmacology
Karina Caballero-Gallardo, Jesus Olivero-Verbel

Abstract

Coal dust is the most important air pollutant in coal mining in regards to producing deleterious health effects. It permeates the surrounding environment threatening public health. The aim of this study was to evaluate the toxic effects associated with exposure to sand contaminated with coal dust particles below 38 μm in diameter, obtained from a mineral sample collected in the largest coal mine in South America, La Loma, Cesar, Colombia. Sterilized sand was spiked with coal dust to obtain concentrations ranging from zero to 4% coal dust. To model natural exposure, mice were housed for eight weeks in boxes containing this mixture as bedding after which, they were euthanized and blood and tissue samples were collected. Real time PCR analysis revealed an increase in Cyp1A1 mRNA for living on sand with coal dust concentrations greater than 2% compared to mice living on sand without coal dust. Unexpectedly, for mice on coal dust-polluted sand, Sod1, Scd1 and Nqo1 hepatic mRNA were downregulated. The Comet assay in peripheral blood cells and the micronucleus test in blood smears, showed a significant potential genotoxic effect only at the highest coal dust concentration. Histopathological analysis revealed vascular congestion and pe...Continue Reading

References

Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·R B FinkelmanB Zheng
Dec 13, 2000·Mutation Research·G Krishna, M Hayashi
May 6, 2004·Journal of Environmental Management·S K Chaulya
Sep 15, 2004·Environmental Research·Ricardo A PinhoJosé Cláudio F Moreira
Feb 3, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Edoardo G GianniniVincenzo Savarino
Apr 19, 2005·Expert Review of Molecular Diagnostics·Manit AryaHitendra R H Patel
Aug 20, 2005·Advances in Physiology Education·Mark A Valasek, Joyce J Repa
Nov 5, 2005·Brain Research. Brain Research Reviews·Christopher D Toscano, Tomás R Guilarte
May 8, 2007·Archives of Biochemistry and Biophysics·Kaname Kawajiri, Yoshiaki Fujii-Kuriyama
Mar 28, 2008·Cancer Letters·Mario E Goetz, Andreas Luch
Nov 13, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Srikanth S NadadurDaniel L Costa
Feb 18, 2009·Seminars in Respiratory and Critical Care Medicine·Robert A C CohenFrancis H Y Green
Jul 27, 2010·Environmental Research·Jairo José ZoccheVanessa Moraes de Andrade
Jan 11, 2011·The Science of the Total Environment·Grethel León-MejíaMilton Quintana
Sep 1, 2007·Environmental Toxicology and Pharmacology·Ferah ArmutcuAhmet Gurel
Jan 3, 2012·Journal of Photochemistry and Photobiology. B, Biology·Guillermo M Zúñiga-GonzálezMartha P Gallegos-Arreola
Jun 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rachel TanosGary H Perdew
Jul 12, 2012·Oncology Letters·Kyriaki PliarchopoulouDimitrios Pectasides
Oct 12, 2012·Environmental and Molecular Mutagenesis·Paula RohrKátia Kvitko
Jan 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shelli SchomakerJiri Aubrecht
Apr 13, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Saber Abdelkader SaïdiAbdelfattah El-Feki
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Edward L PetsonkRobert Cohen
Apr 24, 2013·International Journal of Hygiene and Environmental Health·Jingfu MoMin Su
Jun 4, 2013·Ecotoxicology and Environmental Safety·Nadia Coronado-PosadaJesus Olivero-Verbel
Jun 6, 2013·American Journal of Industrial Medicine·Robert C StansburyEdward L Petsonk
Aug 27, 2013·Archives of Environmental Contamination and Toxicology·Jairo José ZoccheRicardo Aurino Pinho
Sep 6, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Paula RohrJuliana da Silva
Nov 14, 2013·Scandinavian Journal of Work, Environment & Health·Øyvind OmlandSven Viskum
Feb 15, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Angélica Guerrero-CastillaJosé Marrugo-Negrete
Apr 24, 2014·Environmental Monitoring and Assessment·Ting FangPaul Kwan Sing Lam
Jun 14, 2014·Ecotoxicology and Environmental Safety·Grethel León-MejíaJuliana Da Silva

❮ Previous
Next ❯

Citations

Jul 6, 2016·Archives of Toxicology·M GleiW Schlörmann
Jun 20, 2020·Environmental Science and Pollution Research International·Mengyao WangZhijun Huang
Jan 25, 2020·Ecotoxicology and Environmental Safety·Giulia Dos Santos Pedroso-FidelisRicardo Aurino Pinho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.