Mice lacking Bmp6 function

Developmental Genetics
M J SollowayE J Robertson

Abstract

Bmp6, a member of the 60A subgroup of bone morphogenetic proteins (BMPs), is expressed in diverse sites in the developing mouse embryo from preimplantation stages onwards. To evaluate roles for Bmp6 signaling in vivo, gene targeting was used to generate a null mutation at the Bmp6 locus. The resulting Bmp6 mutant mice are viable and fertile, and show no overt defects in tissues known to express Bmp6 mRNA. The skeletal elements of newborn and adult mutants are indistinguishable from wild-type. However, careful examination of skeletogenesis in late gestation embryos reveals a consistent delay in ossification strictly confined to the developing sternum. In situ hybridization studies in the developing long bones and sternum show that other BMP family members are expressed in overlapping domains. In particular we find that Bmp2 and Bmp6 are coexpressed in hypertrophic cartilage, suggesting that Bmp2 may functionally compensate in Bmp6 null mice. The defects in sternum development in Bmp6 null mice are likely to be associated with a transient early expression of Bmp6 in the sternal bands, prior to ossification. These sternal defects are slightly exacerbated in Bmp5/6 double mutant animals.

References

Mar 1, 1992·Trends in Genetics : TIG·V Rosen, R S Thies
Sep 1, 1991·European Journal of Immunology·E K BikoffE J Robertson
Feb 1, 1985·The Journal of Cell Biology·T M Schmid, T F Linsenmayer
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K LyonsR Derynck
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A H Reddi, C Huggins
Feb 1, 1968·The Journal of Experimental Zoology·M C Green
May 25, 1995·Biochemical and Biophysical Research Communications·A AonoY Fujisawa
Nov 1, 1994·Developmental Biology·J A KingD M Kingsley
Jan 1, 1994·Trends in Genetics : TIG·D M Kingsley
Jan 1, 1993·Methods in Enzymology·R Ramírez-SolisA Bradley
Aug 13, 1993·Cell·G H Thomsen, D A Melton
Jul 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T IkedaS Yoshiki
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A T Dudley, E J Robertson
Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S E GitelmanR Derynck

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Citations

Feb 28, 2006·Journal of Bone and Mineral Metabolism·Fumitaka KugimiyaUng-Il Chung
Mar 3, 2009·Nature Genetics·Delphine MeynardMarie-Paule Roth
Mar 3, 2009·Nature Genetics·Billy AndriopoulosJodie L Babitt
Apr 2, 2009·Nature Genetics·Clara Camaschella
Feb 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivan P MoskowitzChristine E Seidman
Aug 13, 2010·Biology of Reproduction·Koji SugiuraJohn J Eppig
Aug 13, 2011·Biology of Reproduction·Michelle MyersStephanie A Pangas
Aug 21, 2001·Genes & Development·D M PanchisionR D McKay
Mar 6, 2002·Genes & Development·Yuko MuroyamaShinji Takada
Aug 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Alexander RosendahlPaschalis Sideras
Mar 11, 2009·BMC Developmental Biology·Trevor L CameronJohn F Bateman
Feb 22, 2008·Development·Amy E MerrillRichard A Schneider
Jun 7, 2007·Journal of Cell Science·Xiaohong TanXiao Yang
Mar 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rama GarimellaH Clarke Anderson
Dec 20, 2008·PLoS Genetics·Catherine GuentherDavid M Kingsley
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Phil G Knight, Claire Glister
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Rebecca L JonesLois A Salamonsen
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Apr 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karen E SearsLee A Niswander
May 25, 2011·The Journal of Cell Biology·Deanna G WilsonMark J Solloway
Aug 2, 2014·Connective Tissue Research·Veronika OralováEva Matalová
May 29, 2015·Biotechnology, Biotechnological Equipment·Xiyan WangBangsheng Xu
May 20, 2016·Journal of Agricultural and Food Chemistry·Chao-Jie WangXuesong Yang
Apr 30, 2003·Genesis : the Journal of Genetics and Development·Jean M HébertSusan K McConnell
Feb 27, 2007·Molecular and Cellular Neurosciences·Pei-Yu WangIan S McLennan
Jun 14, 2005·Brain Research. Brain Research Reviews·Paula Alexandre, Marion Wassef
Apr 14, 2005·Domestic Animal Endocrinology·Victoria BrankinMorag G Hunter
Sep 2, 2014·The American Journal of Pathology·Liangliang ZhaoJoshua L Dunaief
Nov 18, 2014·Genes & Diseases·Richard N WangLewis L Shi
Oct 7, 2014·Toxicology and Applied Pharmacology·Xin ChengXuesong Yang
Apr 30, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xin ChengXuesong Yang

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