PMID: 18414056Apr 17, 2008Paper

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype

Cell Cycle
Nicolas BissonTom Moss

Abstract

The mitogen-activated protein kinase kinase kinases of the mixed-lineage kinase (MLK) family have been shown to activate the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathway, and to regulate the other two principal MAPK cascades, p38 and extracellular signal-regulated kinase (ERK). Although there is growing evidence for their involvement in neuronal cell death leading to neurodegenerative disorders, little in vivo data is available for the members of this family of kinases. Here, we report that the inactivation of mouse Mlk1 and Mlk2 genes. Mlk1(-/-) and Mlk2(-/-) mice were found to be viable and healthy. Surprisingly, mice carrying the compound Mlk1/Mlk2 null mutations were also found to be viable, fertile and to have a normal life span. The nervous system, testis and kidney, the major sites of MLK1 and 2 expression, all appear normal, as do other organs where these kinases were found to be more weakly expressed. Surprisingly, developmental neuronal programmed cell death, another potential target for MLK family members, was also found to be unaffected. Our results suggest that there is extensive functional redundancy between MLK1/MLK2 and the other member of the family, MLK3, which is also not requ...Continue Reading

Citations

Oct 26, 2010·Antioxidants & Redox Signaling·Kohsuke TakedaHidenori Ichijo
Oct 14, 2009·Molecular and Cellular Biology·Cédric ChaverouxPierre Fafournoux
Aug 26, 2010·Journal of Cell Science·Rebecca A GarlenaBeth Stronach
Oct 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Evisabel A CraigTodd D Camenisch
Jun 5, 2016·Biochimica Et Biophysica Acta·Siobhan M CraigeShashi Kant
May 27, 2016·American Journal of Physiology. Renal Physiology·Greg H TeschDavid J Nikolic-Paterson
May 16, 2021·Immunity & Ageing : I & a·Daniel K FabianJanet M Thornton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis