Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan

Proceedings of the National Academy of Sciences of the United States of America
K Y Kwan, J C Wang

Abstract

Targeted gene disruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIbeta have a shorter life expectancy than their wild-type littermates, however. The mean lifespan of the top3beta(-/-) mice is about 15 months, whereas that of their wild-type littermates is longer than 2 years. Mortality of the top3beta(-/-) nulls appears to correlate with lesions in multiple organs, including hypertrophy of the spleen and submandibular lymph nodes, glomerulonephritis, and perivascular infiltrates in various organs. Because the DNA topoisomerase III isozymes are likely to interact with helicases of the RecQ family, enzymes that include the determinants of human Bloom, Werner, and Rothmund-Thomson syndromes, the shortened lifespan of top3beta(-/-) mice points to the possibility that the DNA topoisomerase III isozymes might be involved in the pathogenesis of progeroid syndromes caused by defective RecQ helicases.

References

Feb 1, 1992·Molecular Microbiology·K Drlica
Nov 1, 1992·Journal of Bacteriology·M E Fernandez-Beros, Y C Tse-Dinh
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A Bjornsti, J C Wang
Jan 1, 1985·Molecular & General Genetics : MGG·K NakayamaH Nakayama
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KusanoI Kobayashi
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F ConfalonieriM Duguet
Apr 12, 1996·Science·C E YuG D Schellenberg
Jan 1, 1996·Annual Review of Biochemistry·J C Wang
Nov 1, 1996·Genetics·A MochizukiY Iwasa
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HanadaH Ikeda
Aug 1, 1997·The Journal of Biological Chemistry·Z LiR J DiGate
Aug 29, 1997·Science·D A SinclairL Guarente
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·W Li, J C Wang
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·K YamagataH Ikeda
Sep 28, 1998·Biochimica Et Biophysica Acta·Y C Tse-Dinh
Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Chakraverty, I D Hickson
Mar 29, 2000·The Journal of Biological Chemistry·L WuI D Hickson
Apr 5, 2000·The Journal of Biological Chemistry·A C DéclaisM Duguet
Apr 27, 2000·Trends in Genetics : TIG·J C Shen, L A Loeb
Jun 22, 2000·The Journal of Biological Chemistry·R J BennettJ C Wang
Jul 13, 2000·Cellular and Molecular Life Sciences : CMLS·J NakuraT Miki
Aug 30, 2000·Cancer·V T ChangH T Thaler
Nov 23, 2000·Nature·G M Martin, J Oshima
Jan 1, 2001·The Journal of Biological Chemistry·W M FrickeS J Brill

❮ Previous
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Citations

Dec 10, 2002·Mechanisms of Ageing and Development·Tetsuya OnoHironobu Ikehata
Mar 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Subhasis MohantyAlbert C Shaw
Apr 19, 2012·The Journal of Biological Chemistry·Stefanie Hartman ChenTao-shih Hsieh
Oct 29, 2003·Antioxidants & Redox Signaling·Toru YoshidaJunji Yodoi
Aug 21, 2012·Antioxidants & Redox Signaling·V Ashutosh Rao
Mar 18, 2011·ILAR Journal·Rong YuanBeverly Paigen
Aug 2, 2006·Molecular and Cellular Biology·Masayuki SekiTakemi Enomoto
Jun 6, 2009·Annual Review of Biochemistry·James C Wang
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tina Wilson-Sali, Tao-Shih Hsieh
Jul 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jody L PlankTao-Shih Hsieh
Mar 19, 2013·Annual Review of Biochemistry·Stefanie Hartman ChenTao-shih Hsieh
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kelvin Y KwanJames C Wang
Feb 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kelvin Y KwanJames C Wang
Sep 11, 2001·Biochemical and Biophysical Research Communications·M Kobayashi, R Hanai
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Rafael Balaña-FouceRosa M Reguera
Jul 9, 2003·The Journal of Cell Biology·Andres F MuroFrancisco E Baralle
Mar 25, 2006·Molecular Microbiology·Zhiyu LiRussell DiGate
Oct 19, 2016·Nature Reviews. Neuroscience·Peter J McKinnon
Jan 11, 2017·Journal of Medicinal Chemistry·Giovanni CapranicoGiovanni Chillemi
Dec 5, 2006·Biochimie·Thierry Viard, Claire Bouthier de la Tour
Jan 2, 2003·Nature Reviews. Drug Discovery·Brian P Zambrowicz, Arthur T Sands
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·James C Wang
Nov 4, 2004·The Journal of Biological Chemistry·Vera A Stupina, James C Wang
Oct 22, 2008·Genesis : the Journal of Genetics and Development·Tae Moon KimPaul Hasty
Feb 20, 2009·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Joseph E DeweeseNeil Osheroff
Sep 17, 2005·Molecular Microbiology·Christopher R LopezE Lynn Zechiedrich
Sep 30, 2005·Cytogenetic and Genome Research·U Eichenlaub-Ritter
Nov 7, 2019·Genes·Seung Kyu Lee, Weidong Wang
Dec 5, 2019·Open Biology·Tao ZhangDamien F Hudson
Apr 12, 2020·The Journal of Biological Chemistry·Anna H Bizard, Ian D Hickson
Jul 14, 2010·European Journal of Immunology·Maren MönnichThomas Boehm

❮ Previous
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