Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Svetlana SemenovaAthina Markou

Abstract

The role of β4-containing nicotinic acetylcholine receptors (nAChRs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear. Wild-type (β4(+/+)) and knockout (β4(-/-)) mice for the nAChR β4 subunit were tested in behavioral tests assessing cognitive function, affective behaviors, and nociception. There were no learning and memory deficits in β4(-/-) mice compared with β4(+/+) mice during the acquisition of the Barnes maze, contextual fear conditioning, and Y maze tasks. In the Barnes maze memory retention test, male β4(-/-) mice showed reduced use of the spatial search strategy, indicating small spatial memory deficits compared with β4(+/+) mice. In the cue-induced fear conditioning memory retention test, β4(-/-) mice exhibited reduced freezing time compared with β4(+/+) mice. Compared with β4(+/+) mice, β4(-/-) mice exhibited decreased anxiety-like behavior in the light-dark box. Depression-like behavior in β4(-/-) mice was decreased in the tail suspension test and increased in the forced swim test compared with β4(+/+) mice. β4(-/-) mice did not differ from β4(+/+) mice in basal nociception but were less sensitive to the antinociceptive effect of nicotine in 2 tests of acute thermal pain. Lack ...Continue Reading

References

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S R HamannW R Martin
Sep 25, 1986·Neuroscience Letters·S R Cohen, R Melzack
Jan 1, 1995·Psychopharmacology·I P Stolerman, M J Jarvis
Jan 1, 1995·Annual Review of Physiology·D S McGehee, L W Role
Jul 26, 1996·The Journal of Biological Chemistry·F WangJ Lindstrom
Dec 24, 1997·Behavioural Brain Research·S MarenM S Fanselow
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·W XuA L Beaudet
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M R PicciottoV Zachariou
Apr 20, 2000·European Journal of Pharmacology·S E FileP J Kenny
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·F BaiP Skolnick
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Nov 19, 2002·Journal of Neurobiology·Edward D Levin
Mar 19, 2003·Behavioural Brain Research·D M BannermanJ N P Rawlins
Sep 13, 2003·The Journal of Pharmacology and Experimental Therapeutics·M I DamajB R Martin
Oct 24, 2003·The Journal of Comparative Neurology·Imran KhanPalmer Taylor
Dec 19, 2003·The Journal of Comparative Neurology·Lorise C GahringScott W Rogers
May 7, 2004·The European Journal of Neuroscience·Lucas LecourtierPeter H Kelly
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramiro SalasMariella De Biasi
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·J W RudyP Matus-Amat
Nov 15, 2006·Learning & Memory·Fiona E HarrisonMichael P McDonald
Mar 24, 2007·Neuroscience and Biobehavioral Reviews·Lucas Lecourtier, Peter H Kelly
Jul 17, 2007·Biochemical Pharmacology·Yann S Mineur, Marina R Picciotto
Apr 23, 2008·Current Protocols in Neuroscience·Jeanne M Wehner, Richard A Radcliffe
Nov 11, 2008·Behavioural Brain Research·F E HarrisonM P McDonald
Feb 3, 2009·Handbook of Experimental Pharmacology·Allan C CollinsSharon R Grady
May 2, 2009·Biochemical Pharmacology·Martin SarterWilliam M Howe
Apr 20, 2010·The Journal of Pharmacology and Experimental Therapeutics·K J JacksonM I Damaj
May 21, 2010·Nature Reviews. Neuroscience·Jean-Pierre Changeux
Jul 14, 2010·Current Psychiatry Reports·Aryeh I Herman, Mehmet Sofuoglu
Oct 11, 2011·Journal of Neuroscience Methods·Timothy P O'Leary, Richard E Brown

❮ Previous
Next ❯

Citations

Jul 28, 2015·Nature Neuroscience·Jianxun WangMichael G Rosenfeld
Mar 1, 2015·Neuropharmacology·Dimitris N XanthosPetra Scholze
Aug 25, 2015·Current Addiction Reports·Darlene H BrunzellClaire I Dixon
Jan 14, 2021·International Journal of Molecular Sciences·Pawel GrocheckiJolanta H Kotlinska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.