Mice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection

Journal of Virology
Yuri MartinaD R Salomon

Abstract

Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate the risks associated with PERV transmission to human patients by pig tissue xenotransplantation or to study the potential pathogenesis associated with PERV infection. In previous work we isolated two genes encoding functional human PERV receptors and proved that introduction of these into mouse fibroblasts allowed the normally nonpermissive mouse cells to become productively infected (T. A. Ericsson, Y. Takeuchi, C. Templin, G. Quinn, S. F. Farhadian, J. C. Wood, B. A. Oldmixon, K. M. Suling, J. K. Ishii, Y. Kitagawa, T. Miyazawa, D. R. Salomon, R. A. Weiss, and C. Patience, Proc. Natl. Acad. Sci. USA 100:6759-6764, 2003). In the present study we created mice transgenic for human PERV-A receptor 2 (HuPAR-2). After inoculation of transgenic animals with infectious PERV supernatants, viral DNA and RNA were detected at multiple time points, indicating productive replication. This establishes the role of HuPAR-2 in PERV infection in vivo; in addition, these transgenic mice represent a new model for determining the risk of PERV transmission and potential pathogenesis. These mice als...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F Wong-StaalR C Gallo
Mar 1, 1991·Journal of Virology·J P StoyeJ M Coffin
Nov 30, 1995·The New England Journal of Medicine·L E ChapmanP D Noguchi
Oct 24, 1997·Nature·P Le TissierR A Weiss
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J BrowningH Goldstein
Apr 29, 1998·Journal of Virology·D E AkiyoshiJ A Fishman
Aug 15, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·U MartinA Haverich
Nov 13, 1998·Journal of Virology·Y TakeuchiJ P Stoye
Dec 10, 1999·Journal of Virology·C A WilsonM J Federspiel
Mar 23, 2000·Journal of Virology·R MarianiN R Landau
Apr 13, 2000·The Journal of Infection·R A WeissY Takeuchi
Jul 25, 2000·Journal of Virology·J H BluschU Martin
Jan 3, 2001·Transplantation Proceedings·Y Takeuchi
Feb 27, 2001·Journal of Virology·C PatienceR A Weiss
May 1, 2001·Nature Medicine·S L ButlerF D Bushman
Feb 28, 2002·Journal of Virology·Beth A OldmixonClive Patience
Jun 13, 2002·Xenotransplantation·Jürgen H BluschUlrich Martin
Feb 20, 2003·Transplantation Proceedings·L ZhangP Yu
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas A EricssonClive Patience
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Aug 22, 2003·Reviews in Medical Virology·Saema MagreBirke Bartosch
Sep 6, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Markus IrgangJoachim Denner
Jan 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·L GROSS

❮ Previous
Next ❯

Citations

Jan 18, 2007·Immunology and Cell Biology·Sarah K PoppCharmaine J Simeonovic
Apr 12, 2012·Clinical Microbiology Reviews·Joachim Denner, Ralf R Tönjes
Jul 17, 2009·Journal of Virology·Weerachai JaratlerdsiriJaime Gongora
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·W Ian Lipkin
Mar 12, 2010·Uirusu·Takayuki Miyazawa
Mar 18, 2008·Lancet·Piero RuggenentiGiuseppe Remuzzi
Mar 24, 2007·Alcoholism, Clinical and Experimental Research·Marion PavlicMartin Wurm
Aug 3, 2007·Journal of Medical Primatology·Robin A Weiss
Jun 14, 2006·Xenotransplantation·Reto M Baertschiger, Leo H Buhler
Nov 8, 2007·Reviews in Medical Virology·Derrick LouzRob C Hoeben
Nov 17, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Aki YamamotoShuji Miyagawa
Oct 10, 2018·Current Opinion in Organ Transplantation·Anoma Nellore
Jul 2, 2009·Xenotransplantation·Jagdeece RamsoondarDavid Ayares
May 15, 2018·Xenotransplantation·Joachim DennerHenk-Jan Schuurman
Jan 24, 2007·Gastroenterology·Sanjeev Gupta
Sep 15, 2007·Diabetes Research and Clinical Practice·C LimbertJ Seufert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Yuri MartinaD R Salomon
Proceedings of the National Academy of Sciences of the United States of America
Thomas A EricssonClive Patience
© 2021 Meta ULC. All rights reserved