Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity

Molecular and Cellular Biology
K IbaU M Wewer

Abstract

Tetranectin is a plasminogen-binding, homotrimeric protein belonging to the C-type lectin family of proteins. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. To test the functional role of tetranectin directly, we have generated mice with a targeted disruption of the gene. We report that the tetranectin-deficient mice exhibit kyphosis, a type of spinal deformity characterized by an increased curvature of the thoracic spine. The kyphotic angles were measured on radiographs. In 6-month-old normal mice (n = 27), the thoracic angle was 73 degrees +/- 2 degrees, while in tetranectin-deficient 6-month-old mice (n = 35), it was 93 degrees +/- 2 degrees (P < 0.0001). In approximately one-third of the mutant mice, X-ray analysis revealed structural changes in the morphology of the vertebrae. Histological analysis of the spines of these mice revealed an apparently asymmetric development of the growth plate and of the intervertebral disks of the vertebrae. In the most advanced cases, the growth plates appeared disorganized and irregular, with the disk material protruding through the growth...Continue Reading

References

Nov 1, 1978·American Journal of Diseases of Children·F HalalC Fraser
Sep 20, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·L HerederoA Dorticós
Feb 1, 1992·Muscle & Nerve·L R BridgesR M Mason
Aug 31, 1992·FEBS Letters·L Berglund, T E Petersen
Jan 1, 1992·Journal of Medical Genetics·L McKenzie, D Sillence
Jun 1, 1989·Journal of Medical Genetics·A FindlayJ M Connor
Sep 1, 1988·Cancer·B A Jensen, I Clemmensen
Jan 1, 1987·Acta paediatrica Scandinavica·O G Nielsen, P Pilgaard
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M Aufdermaur, M Spycher
Dec 1, 1994·The Journal of Cell Biology·U M WewerR Albrechtsen
Jan 23, 1995·Gene·C B SørensenT E Petersen
Oct 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K IbarakiM F Young
Jun 1, 1997·Journal of the American Geriatrics Society·K E EnsrudS R Cummings
Dec 31, 1997·Gene·C B SørensenT E Petersen
Dec 30, 1998·APMIS. Supplementum·C K Høgdall
Oct 6, 1999·Current Opinion in Structural Biology·K Drickamer
Jan 26, 2000·Menopause : the Journal of the North American Menopause Society·G I Gorodeski
Jan 26, 2000·Menopause : the Journal of the North American Menopause Society·F L Bellino
May 3, 2000·The Journal of Clinical Investigation·A M DelanyE Canalis
Aug 25, 2001·Journal of Muscle Research and Cell Motility·X XuU M Wewer

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Citations

Jan 17, 2012·European Journal of Applied Physiology·Jeremy P Loenneke, Takashi Abe
Apr 17, 2013·Journal of Bone and Mineral Metabolism·Kousuke IbaToshihiko Yamashita
May 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Birgitte StoevringMichael Christiansen
Nov 25, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Glenn S Gerhard, Claudia J Kasales
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shaohua FanAxel Meyer
Oct 19, 2005·Journal of Biomedical Optics·Adele Boskey, Richard Mendelsohn
Mar 14, 2007·Molecular and Cellular Biology·Katrin DrillerAlbrecht E Sippel
Dec 31, 2005·Molecular and Cellular Biology·Helene BaribaultHui Tian
Mar 30, 2004·Journal of Clinical Pathology·P ObristM Christiansen
May 9, 2014·Stem Cells and Development·Sandra NoackAndrea Hoffmann
May 27, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Koichi SasakiYasuo Kokai
Jan 28, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Liang WangXuefeng Wang
Dec 16, 2005·The Journal of Investigative Dermatology·Andrea K SmileyDorothy M Supp
Dec 13, 2005·The FEBS Journal·Alex N Zelensky, Jill E Gready
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kousuke IbaToshihiko Yamashita
Mar 24, 2015·Biochemical and Biophysical Research Communications·Jihyun ParkJihoe Kim
Nov 15, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·B StoevringM Christiansen
Dec 10, 2013·Bone·Subhash C JunejaArchibald S Perkins
May 10, 2002·The American Journal of Pathology·Nobuko KawaguchiUlla M Wewer
Dec 14, 2016·Journal of Cellular Biochemistry·Sandra StrassburgFilip Simunovic
Mar 5, 2004·Human Molecular Genetics·Katherine I Oravecz-WilsonTheodora S Ross
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masato OkudaShin-ichi Nishikawa
Apr 17, 2020·Science Translational Medicine·Weiqiang ChenHaichao Wang
Jul 18, 2012·Molecular Cancer Therapeutics·Joshua E AllenWafik S El-Deiry
Jan 17, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Megumi HanakaToshihiko Yamashita
Feb 20, 2021·Stem Cell Reports·Chase A PaganiBenjamin Levi

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