Abstract
An approach combining micellar electrokinetic chromatography fingerprinting with chemometrics was developed to evaluate the quality consistency of Lianqiao Baidu pills, which are traditional Chinese patent medicines composed of 19 herbs used mainly to treat skin ulcers, common cold, rheumatism, herpes, and constipation. The triangle optimization method was employed to choose a satisfactory background electrolyte, with the information index, I, as an objective function for assessing the capillary electrophoresis conditions. Then, under the optimal conditions, the micellar electrokinetic chromatography fingerprints of 28 batches of samples were established, and five marker compounds were quantitatively determined simultaneously. A limited-ratio quantified fingerprint method was introduced to evaluate the chromatographic fingerprints both qualitatively and quantitatively. Principle component analysis revealed that the 28 batches of samples can be clustered according to different manufacturers. Moreover, the relationship between the fingerprint and the antioxidant activity was explored by orthogonal partial least-squares regression, which provided critical medicinal efficacy information for quality control. The present study establ...Continue Reading
References
Jul 13, 2006·Journal of Separation Science·Shaban ElostaJosef Havel
Jul 27, 2007·Journal of Separation Science·José Manuel Herrero-MartínezClara Ràfols
Oct 19, 2007·Journal of Chromatography. a·G AlaertsY Vander Heyden
Jul 11, 2008·Journal of Separation Science·Shao LiuYi-Zeng Liang
Feb 11, 2009·Planta medica·Arnold VlietinckSandra Apers
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Na DingCheng-Xi Cao
Sep 18, 2010·Phytochemical Analysis : PCA·Qing-Feng Zhang, Hon-Yeung Cheung
Nov 30, 2011·Analytica Chimica Acta·J Ricardo Lucio-GutiérrezS Maspoch
Jul 17, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·S ThiangthumY Vander Heyden
Jul 18, 2012·Journal of Ethnopharmacology·K K NyirendaC J F Muller
Nov 20, 2012·Talanta·Ghada M HadadMostafa K Mesbah
Dec 12, 2012·Journal of Separation Science·María del Pilar Godoy-CaballeroMaría Isabel Acedo-Valenzuela
Nov 26, 2013·Analytica Chimica Acta·Mohammad GoodarziYvan Vander Heyden
Jul 30, 2014·Journal of Chromatography. a·Hui SunYing Sing Fung
Oct 7, 2014·Journal of Chromatography. a·Joanna OrzelBeata Walczak
Dec 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Qing MiaoMeihua Yang
Feb 17, 2015·Journal of Pharmaceutical and Biomedical Analysis·Wiktoria Struck-LewickaMichał J Markuszewski
Mar 5, 2015·Journal of Separation Science·Mauro ForteschiCiriaco Carru
Apr 18, 2015·Journal of Separation Science·Jiye ChenXiaohuan Wang
Mar 13, 2016·Journal of Pharmaceutical and Biomedical Analysis·Xin HuShuihan Zhang
Citations
Nov 6, 2018·Journal of Separation Science·Jing Zhang, Guoxiang Sun
Jun 10, 2020·Chinese Medicine·Xi-Chuan WeiDing-Kun Zhang
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcin GackowskiArtur Bogacz