Miconazole, a pharmacological barrier to skin fungal infections

Expert Opinion on Pharmacotherapy
Gérald E PiérardClaudine Piérard-Franchimont

Abstract

Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic methylated sterols occurs and the synthesis of triglycerides and phospholipids is altered. Disturbances in oxidative and peroxidative enzyme activities lead to an intracellular toxic concentration of hydrogen peroxide. As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria. This review aims at revisiting the MCZ antifungal activity in dermatomycoses. MCZ's wide spectrum of activity appears noteworthy. The full pharmacological profile of MCZ indicates its fungistatic profile through its effect on ergosterol biosynthesis. In addition, it exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation. MCZ is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of derm...Continue Reading

References

Mar 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M BorgersH Van Belle
Apr 1, 1988·Clinical Microbiology Reviews·R A Fromtling
Jul 1, 1988·Contact Dermatitis·C M Perret, R Happle
Aug 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·F C OddsP F Troke
Jan 1, 1972·Chemotherapy·J M Van Cutsem, D Thienpont
Jan 1, 1993·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·G E PiérardJ A Estrada
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·A J Carrilo-MuñozJ Torres
Mar 1, 1996·Contact Dermatitis·L FernandezS Duque
Sep 18, 2002·Antimicrobial Agents and Chemotherapy·Daisuke KobayashiNaoki Watanabe
Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Jorge E Arrese, Gérald E Piérard
May 6, 2004·Medical Mycology·C S OsborneN S Ryder
May 25, 2004·Antimicrobial Agents and Chemotherapy·Jacob M Hornby, Kenneth W Nickerson
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Raluca DumitruKenneth W Nickerson
Apr 7, 2006·Expert Review of Anti-infective Therapy·Annette W Fothergill
Jun 8, 2007·The Journal of Biological Chemistry·Karin ThevissenIsabelle E J A François
Jun 19, 2007·International Journal of Pharmaceutics·Valéry BarillaroGeraldine Piel
May 15, 2008·Mycopathologia·Aditya K Gupta, Elizabeth A Cooper
May 28, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·P QuatresoozG E Piérard
May 29, 2008·Future Microbiology·Andrei Barasch, Andreea Voinea Griffin
Jul 17, 2008·Expert Opinion on Pharmacotherapy·Pascale QuatresoozGérald E Piérard
Nov 6, 2008·Dermatologic Clinics·Dirk M Elston
Apr 30, 2009·Expert Review of Anti-infective Therapy·Javier PemánAna Espinel-Ingroff
Jun 18, 2009·Mycoses·N Isham, M A Ghannoum
Aug 1, 2009·Mycopathologia·Gérald E PiérardPascale Quatresooz
May 12, 2010·Expert Review of Anti-infective Therapy·Naomi Musaji
Jun 9, 2010·Acta Dermato-venereologica·Mikael AlsterholmJan Faergemann
Jul 6, 2010·International Journal of Pharmaceutics·Ana M CerdeiraBruno Gander
Jul 27, 2010·European Journal of Clinical Pharmacology·Nancy Broos, Eugène P van Puijenbroek
Aug 31, 2010·Southern Medical Journal·Jeremy L ThomasAndrea S Franks
Oct 27, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katarzyna SobierajskaHanna Fabczak
Dec 3, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Aguinaldo Silva GarcezMartha Simões Ribeiro
Dec 22, 2010·Expert Review of Anti-infective Therapy·Rajesh V Lalla, René-Jean Bensadoun
Jan 29, 2011·Archives of Oral Biology·Guo-Xian WeiChristine D Wu
Feb 22, 2011·Journal of Clinical Pharmacy and Therapeutics·M KovacZ Kovac
Jul 13, 2011·Antimicrobial Agents and Chemotherapy·Anna BinkKarin Thevissen

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Citations

Dec 25, 2012·Archives of Pharmacal Research·Bram BaertBart De Spiegeleer
Jul 30, 2014·Cellular Oncology (Dordrecht)·Jee-Young ParkWon-Ki Baek
Apr 19, 2013·Mycoses·Stefano Veraldi
Jun 7, 2013·Medicinal Research Reviews·Ling ZhangCheng-He Zhou
Feb 6, 2017·Disease Models & Mechanisms·Ran YangJing-Wei Xiong
Jun 6, 2018·Frontiers in Microbiology·Omar Y MadyLamiaa A Al-Madboly
Jun 3, 2021·Antibiotics·Anne Caroline Morais CaldeirãoDouglas Roberto Monteiro
Jun 26, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Gleiston G DiasEufrânio N da Silva Júnior
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan
Nov 14, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Amira M El-GaninyHisham A Abbas

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