Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study.

AAPS PharmSciTech
Tarek A AhmedAlia A Badawi

Abstract

The interest in and need for formulating miconazole nitrate (MN), a broad-spectrum antifungal, as an oral disintegrating tablet for treatment of some forms of candidiasis have increased. Formulation of MN in this dosage form will be more advantageous, producing dual effect: local in the buccal cavity and systemic with rapid absorption. Four formulations were prepared utilizing the foam granulation technique. The prepared tablets were characterized by measuring the weight uniformity, thickness, tensile strength, friability, and drug content. In addition, tablet disintegration time, in vitro dissolution, and in vivo disintegration time were also evaluated. Stability testing for the prepared tablets under stress and accelerated conditions in two different packs were investigated. Each pack was incubated at two different elevated temperature and relative humidity (RH), namely 40 ± 2°C/75 ± 5% RH and 50 ± 2°C/75 ± 5% RH. The purpose of the study is to monitor any degradation reactions which will help to predict the shelf life of the product under the defined storage conditions. Finally, in vivo study was performed on the most stable formula to determine its pharmacokinetic parameters. The results revealed that all the prepared table...Continue Reading

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Citations

Nov 13, 2018·Biomedical Chromatography : BMC·Manuel Humberto Cháirez-RamírezNuria Elizabeth Rocha-Guzmán
Sep 12, 2018·Antimicrobial Agents and Chemotherapy·Francesca D'AngeloGiordano Rampioni
Jul 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena BîrsanAdriana Ciurba

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