Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo

Open Access Macedonian Journal of Medical Sciences
Serena GianfaldoniTorello Lotti

Abstract

Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation. The aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTION®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligo. Fifty eight patients had been treated with n-UVB micro-photootherapy (Group A); 9 patients had been treated with phototherapy plus Tofacitinb citrate (Group B). Among Group A, 42 patients (72%) obtained a re-pigmentation rate higher than 75%, with a medium value of 77%. 11 patients (19%) achieved a marked improvement of the clinical findings with a repigmentation rate between 50-75%; 4 patients (8%) showed a moderate response with a lesional repigmentation of 25-50%. Only one patient (1%) had a poor response to the phototherapeutic treatment. Nb - UVB m...Continue Reading

Citations

Jan 21, 2020·Expert Opinion on Emerging Drugs·Priyanka KaragaiahTorello Lotti
Mar 25, 2019·Journal of Cutaneous Medicine and Surgery·Nicole Relke, Melinda Gooderham
Oct 5, 2019·The Journal of Dermatological Treatment·Kyle TegtmeyerPeter A Lio
Mar 24, 2021·Pigment Cell & Melanoma Research·Vishal ThakurDavinder Parsad

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