Micro-CT imaging as a method for comparing perfusion in graduated-height and single-height surgical staple lines

Medical Devices : Evidence and Research
Matthew EschbachAndrew M Miesse

Abstract

Wound healing is a goal for advanced technology in the surgical space to benefit clinical outcomes. Surgical staplers are commonly used in a variety of open and minimally invasive abdominal and thoracic procedures. Assessment of wound healing traits, such as perfusion, has been challenging due to technical limitations. A novel technique that utilizes micro-computed tomography methodology to measure perfusion was designed to compare the micro-perfusion of staple lines between commercial stapler reloads that employ different staple height strategies. Following an Institutional Animal Care and Use Committee-approved protocol, rats were euthanized and immediately heparinized prior to a subtotal gastrectomy with either graduated-height or single-height staples. Rats were then perfused with barium, following which stomachs were removed and immediately fixed in formalin to prevent degradation. Stomachs were then imaged using micro-computed tomography and subsequent analysis was utilized to quantify fluid volume and patent vasculature proximity to staples within the staple line region for each group. Average perfusion volume was significantly higher with graduated-height staples (0.33% ± 0.18%) compared to single-height staples (0.16% ...Continue Reading

Citations

Jul 23, 2020·Veterinary Surgery : VS·Kaitlyn M MullenJames Colee
Oct 23, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Bénédicte BonnetIsabelle Villemure

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Methods Mentioned

BETA
gastric bypass
imaging technique

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Minitab
Excel
MatLab

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