Micro-CT observation of in vivo temporal change in mandibular condyle morphology in BMAL1 knockout mice

Journal of Oral Science
Shigenori HiraiKazuya Honda

Abstract

Brain and muscle Arnt-like protein-1 (BMAL1) knockout mice exhibit accelerated aging, abnormal glucose metabolism, and impaired adipocyte differentiation, among other phenotypes, which are effects associated with the BMAL1 gene. No study has investigated temporal changes in the deformation of the mandibular condyle and the presence of calcification in areas surrounding the mandibular condyle. In a study of 12 C57/BL strain mice under inhalation anesthesia, we collected images of the mandibular condyle at 6 weeks after birth and then every 5 weeks from 10 to 25 weeks after birth. At 25 weeks, deformation of the mandibular condyle was seen in 8 of 12 joints in BMAL1 knockout mice and in 2 of 12 joints in wild-type mice. At 20 and 25 weeks, deformation in areas surrounding the mandibular condyle, which are known to undergo calcification, was seen in 2 of 12 joints in BMAL1 knockout mice and in 0 of 12 joints in wild-type mice. BMAL1 knockout mice exhibited premature aging of the mandibular condyle, which suggests that circadian rhythms affect mandibular condyle morphology.

References

May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B HogeneschC A Bradfield
Aug 15, 1998·Biochemical and Biophysical Research Communications·S TakahataY Fujii-Kuriyama
Feb 13, 1999·Cell·J C Dunlap
Mar 2, 2005·Genesis : the Journal of Genetics and Development·Maureen K BungerChristopher A Bradfield
Aug 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shigeki ShimbaMasakatsu Tezuka
Feb 13, 2009·The Journal of Biological Chemistry·Isabelle M BurXavier Bonnefont

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Citations

Mar 3, 2020·Dental Materials Journal·Hiroko OkawaIchiro Nishimura
Dec 15, 2020·Journal of Oral Science·Ryosuke KoshiKazuya Honda

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