Micro-environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

Diabetes/metabolism Research and Reviews
Xiao ZhuKai Yin

Abstract

The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory diseases. Obesity-associated metabolic dysfunctions, including those of glucose, fatty acid, cholesterol, and other nutrient substrates such as vitamin D and iron in AT, promote the pro-inflammatory polarization of ATMs and AT inflammation via regulating the interaction between ATMs and adipocytes and intracellular metabolic pathways, including glycolysis, fatty acid oxidation, and reverse cholesterol transportation. Focusing on the regulation of ATM metabolism will provide a novel target for the treatment of obesity-related chronic inflammatory diseases, including insulin resistance, cardiovascular diseases, and cancers.

References

Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·J Y KimJ A Houmard
Aug 27, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Takayoshi SuganamiYoshihiro Ogawa
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
Feb 5, 2009·Biological Research for Nursing·Mary Madeline Rogge
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Devadoss J SamuvelYan Huang
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi HirayamaYasushi Matsuzaki
Dec 24, 2009·The Journal of Biological Chemistry·Koji OhashiKenneth Walsh
Jun 1, 2010·Haematologica·Gianfranca CornaPatrizia Rovere-Querini
Sep 14, 2010·Acta Pharmacologica Sinica·Di-xian LuoDuan-fang Liao
Sep 30, 2010·Journal of Neural Transmission·Roberta J WardDavid T Dexter
Jul 9, 2011·Journal of the American College of Cardiology·Yoichiro HirataMasataka Sata
Nov 1, 2011·Acta Pharmacologica Sinica·Zhan-guo Gao, Jian-ping Ye
Apr 28, 2012·Experimental and Molecular Pathology·Gaurav K GuptaDevendra K Agrawal
Sep 22, 2012·The Journal of Clinical Investigation·J Scott GabrielsenDonald A McClain
Jan 10, 2013·Current Opinion in Lipidology·Katrien H J GaensCasper G Schalkwijk
Jan 11, 2013·Physiological Reviews·Paul Trayhurn
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Norbert Leitinger, Ira G Schulman
Jun 7, 2013·EMBO Molecular Medicine·Natalie KrahmerTobias C Walther
Aug 15, 2013·The Journal of Biological Chemistry·Priyajit ChatterjeeSamir Bhattacharya
Oct 8, 2013·PloS One·Christina Camell, C Wayne Smith
Mar 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiangwei XiaoGeorge K Gittes
Jun 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karim C El KasmiKurt R Stenmark
Jun 21, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·David MankaNeal L Weintraub
Jun 25, 2014·Biochimica Et Biophysica Acta·Dmitry Namgaladze, Bernhard Brüne
Jun 28, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Soonkyu ChungJohn S Parks
Sep 28, 2014·Immunobiology·Michaela JungBernhard Brüne
Oct 14, 2014·Frontiers in Immunology·Michael James KraakmanHélène L Kammoun
Oct 15, 2014·Molecular and Cellular Biochemistry·Mrittika ChattopadhyaySasanka Chakrabarti

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Citations

Aug 20, 2018·Current Diabetes Reports·Silvia PieraliceErnesto Maddaloni
Nov 3, 2020·Frontiers in Immunology·Susu M ZughaierAbdulbari Bener
May 1, 2021·Cancers·Candace C Parker, Suzanne E Lapi

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