PMID: 4292909Sep 1, 1967Paper

Micro-iontophoretic studies on neurones in the cuneate nucleus

The Journal of Physiology
A GalindoS Schwartz

Abstract

1. Cuneate cells in anaesthetized cats were strongly excited by L-glutamate, and somewhat less by D-glutamate; cells which receive afferents from hair receptors were particularly sensitive.2. Glutamate could be used to demonstrate post-synaptic inhibitory inputs from the dorsal column, the medial lemniscus and the frontal cortex.3. Many cuneate cells were also strongly excited by adenosinetriphosphate (ATP); this was probably due to the chelating action of ATP, as citric acid was also quite effective.4. gamma-Aminobutyric acid (GABA) readily blocked all forms of spontaneous and evoked activity, except antidromic invasion of cuneothalamic neurones; cells which receive proprioceptive afferents were particularly sensitive to GABA. Glycine had a comparable effect.5. Acetylcholine (ACh), catecholamines, histamine, 5-hydroxytryptamine (5-HT) and an extract containing substance P mostly had only weak depressant actions. Cholinergic and mono-aminergic mechanisms are probably not very significant in the cuneate.6. These results are consistent with the possibility that glutamate and GABA (or glycine), or some closely related compounds, are the main excitatory and inhibitory transmitters in the cuneate nucleus.7. If ATP is released from a...Continue Reading

Citations

Sep 16, 1973·Pflügers Archiv : European journal of physiology·H AltmannR Steinberg
Apr 1, 1979·Neuropharmacology·R L Polzin, C D Barnes
Jul 1, 1974·Neuropharmacology·A Sherman, G F Gebhart
Jan 1, 1970·Experimental Brain Research·L Hösli, A K Tebecis
Jan 1, 1981·Progress in Neurobiology·J W Phillis, P H Wu
May 21, 1999·The European Journal of Neuroscience·A Nuñez, W Buño
Jan 15, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Massimo Avoli, Krešimir Krnjević
Mar 4, 2008·Neuropharmacology·Kresimir Krnjević
Jan 13, 2006·British Journal of Pharmacology·Geoffrey Burnstock
Jan 25, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael M HakkySami H Erbay
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Apr 15, 2005·Neurological Research·John W Phillis
Aug 16, 1974·Brain Research·H L Haas
Apr 25, 1975·Brain Research·G K KostopoulosJ W Phillis
Apr 25, 1975·Brain Research·H L HaasJ C Nussbaumer
Oct 29, 1971·Brain Research·N R Banna, S J Jabbur
Feb 21, 2006·Trends in Pharmacological Sciences·Geoffrey Burnstock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.