Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells

International Journal of Nanomedicine
Ruogu XuFeilong Deng

Abstract

Selective laser melting (SLM) titanium is an ideal option to manufacture customized implants with suitable surface modification to improve its bioactivity. The peri-implant soft tissues form a protective tissue barrier for the underlying osseointegration. Therefore, original microrough SLM surfaces should be treated for favorable attachment of surrounding soft tissues. In this study, anodic oxidation (AO) was applied on the microrough SLM titanium substrate to form TiO2 nanotube arrays. After that, calcium phosphate (CaP) nanoparticles were embedded into the nanotubes or the interval of nanotubes by electrochemical deposition (AOC). These two samples were compared to untreated (SLM) samples and accepted mechanically polished (MP) SLM titanium samples. Scanning electron microscopy, energy dispersive spectrometry, X-ray diffraction, surface roughness, and water contact angle measurements were used for surface characterization. The primary human gingival epithelial cells (HGECs) and human gingival fibroblasts (HGFs) were cultured for cell assays to determine adhesion, proliferation, and adhesion-related gene expressions. For HGECs, AOC samples showed significantly higher adhesion, proliferation, and adhesion-related gene expressio...Continue Reading

Citations

Aug 21, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mariana Lima da Costa ValenteAndréa Cândido Dos Reis
Jul 30, 2020·Materials·Chaker FaresJosephine Esquivel-Upshaw
Jul 11, 2020·Dentistry Journal·Emilia BarkerKeyvan Moharamzadeh
Jan 15, 2021·Acta Biomaterialia·Tianqi GuoSašo Ivanovski
Oct 3, 2020·Advances in Colloid and Interface Science·Marcel F KunrathMaría E Galárraga-Vinueza
Feb 12, 2021·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Marie-Joséphine CrennClaire Bardet
Dec 17, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Anne BernhardtUte Botzenhart
Jul 28, 2021·ACS Biomaterials Science & Engineering·Karan GulatiSašo Ivanovski

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BETA
scanning
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Software Mentioned

SPSS

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