Micro parallel liquid chromatography: enabling technology for discovery analytical chemistry

Assay and Drug Development Technologies
Anthony V LemmoParen Patel

Abstract

Since the introduction of combinatorial chemistry, compound libraries have undergone a significant increase in size and diversity. The ensuing expansion and diversification of compound libraries have resulted in increased demand for analytical throughput. Following the evolution of new technologies for generating lead compounds and targets and the desire to increase research and development productivity, analytical chemistry is now gaining attention as a bottleneck that would benefit from advances in instrumentation for increased analytical throughput. The commercial introduction of the Veloce trade mark micro parallel liquid chromatography system from Nanostream offers discovery analytical chemists the capability to analyze 24 samples in parallel with as little as 0.5 microl of sample. The system offers a scalable analytical approach to address bottlenecks in historically underserved areas, such as compound library purity screening, as well as higher value-added applications, such as log P determination and aqueous solubility assessment. This article describes the Veloce system and presents representative data from several discovery analytical applications.

Citations

Feb 3, 2007·Journal of Pharmaceutical and Biomedical Analysis·Ying LiuJerry Yeh
Aug 24, 2010·Journal of Separation Science·Sten OhlsonRoland Isaksson
Oct 29, 2005·Drug Discovery Today·Johan PihlDaniel T Chiu
May 6, 2005·Assay and Drug Development Technologies·Carsten HaberBart van der Schoot
Jan 4, 2007·Assay and Drug Development Technologies·Jun WuStephen D O'Connor
Dec 15, 2007·Assay and Drug Development Technologies·Anton SimeonovJames Inglese
Aug 29, 2013·Journal of Laboratory Automation·Stefan Borja BammesbergerPeter Koltay

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