Micro-Ribonucleic Acid and Carcinogenesis: Breast Cancer as an Example

Oncology Reviews
Manal Al-Khanbashi, Mansour Al-Moundhri

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have unique functions at post-transcriptional level (epigenetics). MiRNAs play a pivotal role in controlling gene expression at various levels including differentiation, cell-cycle regulation, apoptosis and many others in mammals as well as in many organisms. Recently, there has been greater understanding of the contribution of dysregulation of miRNA into disease status in particular carcinogenesis. In this review, we will discuss miRNA discovery, nomenclature, function, contribution of their dysregulation into disease status in particular carcinogenesis and their potential role as biomarkers.

Citations

Feb 17, 2017·Annals of Surgical Treatment and Research·Ji-Guang HanGuo-Qiang Zhang
Feb 10, 2017·Breast Cancer Research and Treatment·Mithu RaychaudhuriStefanie Avril

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Methods Mentioned

BETA
PCR
xenograft

Software Mentioned

miRanda
TargetScan

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