Micro RNA expression profiles in peripheral blood cells of rats that were experimentally infected with Trypanosoma congolense and different Trypanosoma brucei subspecies

Microbes and Infection
Gustave SimoJörg D Hoheisel

Abstract

To identify miRNAs whose expression are differentially regulated during trypanosome infections a microarray targeting more than 600 rat miRNA was used to analyze the miRNA expression profiles between uninfected rats and animals infected by Trypanosoma congolense and Trypanosoma brucei s.l. The potential targets of dysregulated miRNAs as well as their biological pathways and functions were predicted using several bioinformatics software tools. Irrespective of the infecting trypanosome species, eight miRNAs (seven up- and one down-regulated) were dysregulated during infections. Moreover, other miRNAs were differentially regulated in rats infected by specific trypanosome species. Functional analyses of differentially regulated miRNAs indicated their involvement in diverse biological processes. Among these, transcription repressor activity, gene expression control as well as protein transporter activity were predominant. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of dysregulated miRNAs revealed their involvement in several biological pathways and disease conditions. This suggests possible modulation of such pathways following trypanosome infection; for example, the MAPK signaling pathway which is known to pl...Continue Reading

References

Mar 1, 1990·Molecular and Biochemical Parasitology·G HideA Tait
Jun 1, 1995·Molecular and Biochemical Parasitology·F Mathieu-DaudéM McClelland
Mar 23, 2001·Journal of Leukocyte Biology·B NamangalaA Beschin
Sep 24, 2005·Parasite Immunology·J M Mansfield, D M Paulnock
Feb 10, 2007·Journal of Leukocyte Biology·Konstantin Salojin, Tamas Oravecz
Mar 9, 2007·Genes & Development·Joel R NeilsonPhillip A Sharp
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Dec 1, 2007·Bioinformatics·Xiaowei Wang, Issam M El Naqa
Feb 23, 2008·Seminars in Cancer Biology·Enikö SonkolyAndor Pivarcsi
Oct 8, 2008·Immunological Reviews·Henry TabelMeiqing Shi
Nov 27, 2008·Journal of Cellular Physiology·Yujing BiRuifu Yang
Apr 18, 2009·Journal of Lipid Research·Shengjie LiChen-Yu Zhang
Oct 9, 2009·The New England Journal of Medicine·Junfang JiXin Wei Wang
Mar 9, 2010·BMC Research Notes·Pedro López-RomeroRafael A Irizarry
Feb 22, 2011·Molecular Genetics and Metabolism·Mark BazettChristina K Haston
Sep 6, 2011·Journal of Molecular and Cellular Cardiology·J FiedlerT Thum
Sep 7, 2011·The American Journal of Pathology·Jiamin ChenVictor A Tron
Oct 18, 2011·BMC Genomics·M Aleksi KallioEija I Korpelainen
Feb 5, 2013·Schizophrenia Bulletin·Guglielmo LuccheseDarja Kanduc
Jul 16, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dong WuKai-yu Wang
Jun 10, 2014·International Journal of Cardiology·Ludmila Rodrigues Pinto FerreiraEdecio Cunha-Neto

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Citations

May 23, 2015·Microbes and Infection·Sophia Häfner
Oct 17, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Hossein GhalehnoeiMohammad Amir Mishan

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