Micro-RNA (miRNA): A biomarker to identify novel compounds in drug discovery and delivery for cancer therapy

Current Drug Discovery Technologies
Gokul Paramasivam

Abstract

Micro-RNAs (miRNA) are short non-coding sequences involved in the biological regulatory process. The miRNA shows a unique expression in diseases resulting in the pathogenesis. Identifying the novel compounds are interesting during this process. The miRNA is a biomarker that helps to find the early stage of cancer disease through pathogenesis. Azobenzene and pyrazole are the novel compounds having a cytotoxic effect on cancer cells. These novel compounds are molecular probe used in breast cancer therapy. The viral-based systems have few limitations such as toxicity and immunogenicity. So, the non-viral based lipoplex and polyplex systems are attractive due to no size limitations for the transfection of micro RNAs. The conventional drug delivery systems are having a large size and low drug efficacy at the target site. The nanoparticles prepared by nanoprecipitation methods are attractive in cancer therapy. Thus, the miRNA acts as a powerful tool and is used to identify the drug target in cancer therapy.

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

© 2021 Meta ULC. All rights reserved