Micro-RNAs, Exercise and Cellular Plasticity in Humans: The Impact of Dietary Factors and Hypoxia

MicroRNA
Timothée Watier, Anthony Mj Sanchez

Abstract

Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs. miRNAs have a significant biological impact as they control more than 60% of human genome by targeting specific messenger RNAs. Recent studies conducted in human showed that miRNAs are detectable in a variety of biological fluids such as serum, plasma, saliva, urine and tears. Both endurance and strength exercises modulate the expression of miRNAs coding for actors involved in several cellular processes related to training adaptation. In this review, we discuss recent advances on the development of methods for miRNAs detection and the impact of acute and chronic exercise on their modulation in humans. We especially highlight the most recent studies on the factors that can impact miRN...Continue Reading

Citations

Mar 6, 2018·Canadian Journal of Physiology and Pharmacology·Bo ChuYun Li
Oct 31, 2019·Menopause : the Journal of the North American Menopause Society·Tilen KranjcBarbara Ostanek
Feb 20, 2021·Journal of Exercise Science and Fitness·Thibaut MélineAnthony Mj Sanchez
Apr 4, 2021·International Journal of Molecular Sciences·Robert SolsonaAnthony Mj Sanchez

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