Micro-solid phase extraction of perfluorinated carboxylic acids from human plasma

Journal of Chromatography. a
Maryam Lashgari, Hian Kee Lee

Abstract

Micro-solid phase extraction (μ-SPE), with liquid chromatography-tandem mass spectrometry has been developed for the determination of trace levels of perfluorinated carboxylic acids (PFCAs) in human plasma. The μ-SPE sorbent was surfactant-templated mesoporous silica. Extraction time, desorption time and salt concentration were chosen as the most effective parameters and were optimized simultaneously by use of central composite design. Under the optimized extraction conditions, good linearity in the range of 100 and 5000ngL(-1) was obtained with coefficients of determination of between 0.986 and 0.995. The limits of detection (at a signal to noise ratio of 3) were measured to be in the range of between 21.23 and 65.07ngL(-1), and limits of quantification (at a signal to noise ratio of 10) were in the range of between 70.77 and 216.92ngL(-1). The relative recoveries of spiked PFCAs in different samples were in the range of between 87.58 and 102.45%. As expected from the global distribution of PFCs, contaminations at low levels (less than 200ngL(-1)) were detected (with the highest concentration recorded for perfluorooctanoic acid (PFOA)). Considering the complex nature of biological samples and the issue of matrix effects in the...Continue Reading

References

May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
Dec 4, 2003·Environmental Health Perspectives·Geary W OlsenLarry R Zobel
Jul 21, 2004·Environmental Science & Technology·David A EllisTimothy J Wallington
Oct 6, 2004·Environmental Science & Technology·Kurunthachalam KannanKenneth M Aldoust
Jul 3, 2007·Analytical Chemistry·Barbara S Larsen, Mary A Kaiser
Dec 17, 2009·Journal of Chromatography. a·Fabio GosettiMaria Carla Gennaro
Oct 30, 2010·Journal of Environmental Monitoring : JEM·Lutz Ahrens
Feb 26, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Guang-Wen LienPau-Chung Chen
Jul 29, 2011·Critical Reviews in Food Science and Nutrition·Yolanda PicóDamià Barceló
Aug 27, 2011·Environmental Science & Technology·Andrew B LindstromE Laurence Libelo
Feb 16, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·D Brynn Hibbert
Oct 31, 2012·Analytical and Bioanalytical Chemistry·Sara ValsecchiStefano Polesello

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Citations

Sep 14, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Olga FilippouVictoria Samanidou
Dec 13, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Oct 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takuya FujiwaraMakoto Tsunoda

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