Microalbuminuria as an early marker of renal involvement in Behcet's disease: it is associated with neurological involvement and duration of the disease

Journal of the European Academy of Dermatology and Venereology : JEADV
M KavalaS Südogan

Abstract

Despite its nature as a systemic vasculitis, renal involvement is known to occur infrequently in Behçet's Disease (BD). Our aim was to investigate proteinuria, microhematuria and microalbuminuria in 24-h urine and evaluate subclinical or symptomatic renal involvement in BD patients. Two hundred and eleven patients who fulfilled the International Behçet's Disease criteria were included in the study. After urine analysis, five of 12 patients who were found to have proteinuria underwent renal biopsy, while 199 patients without proteinuria were investigated for microalbuminuria (MA). A total of 34 (16.1%) patients were found to have renal involvement including 22 (11.1%) with MA and 12 with proteinuria (5.6%). Renal biopsies resulted as focal glomerulosclerosis in three, membranous glomerulosclerosis in one and secondary amyloidosis in two patients. Neurological involvement was found to be significantly more prevalent in patients with MA (P < 0.01). Neurological involvement and duration of disease (> or = 10 years) was found to increase the risk for MA by 21.75-fold and 5.03-fold, respectively. Though age over 40 years, thrombophlebitis, HLA B51 haplotype and ophthalmological involvement were not found to be significantly associate...Continue Reading

References

Feb 1, 1988·Annals of the Rheumatic Diseases·N DilşenE Ozdogan
Jun 10, 1998·British Journal of Rheumatology·M DuarteJ A Bosch
Apr 17, 2002·Clinical Rheumatology·M R AltiparmakV Hamuryudan
Apr 20, 2002·Seminars in Arthritis and Rheumatism·Tekin AkpolatSeza Ozen
Apr 16, 2004·Renal Failure·Idris SahinTekin Akpolat
Oct 14, 2006·Clinical Rheumatology·Umut UtkuTekin Akpolat
Jan 29, 2008·Seminars in Arthritis and Rheumatism·Tekin AkpolatIlkser Akpolat

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Citations

Dec 12, 2012·Yonsei Medical Journal·Sung Bin ChoDongsik Bang
Nov 21, 2012·Ocular Immunology and Inflammation·Annabelle A OkadaKhalid Tabbara

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