Microalbuminuria as surrogate endpoint in therapeutic trials.

Current Hypertension Reports
Josep Redon, Fernando Martinez

Abstract

A surrogate endpoint is a measure of the effect of a certain treatment that may correlate with a real clinical endpoint but does not necessarily have a guaranteed relationship. The concept is particularly useful in cardiovascular and renal disease. We review evidence regarding microalbuminuria as one potential surrogate endpoint. In diabetes, hypertension and high cardiovascular risk, recent studies have demonstrated the prognostic value of significant changes in urinary albumin excretion for cardiovascular and renal outcomes. The most appropriate timing with which to repeat microalbuminuria and whether or not changes should be targeted during the antihypertensive treatment remain unanswered.

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Citations

May 8, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nilufer GoknarYasar Cesur
May 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Erum A Hartung
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Oct 27, 2016·Journal of Hypertension·Teresa M SecciaLorenzo A Calò
Aug 22, 2018·Journal of Human Hypertension·Yu-Qing HuangYing-Qing Feng
May 23, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernando MartínezJosep Redon

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