Microalbuminuria, cardiovascular autonomic dysfunction, and insulin resistance in patients with type 2 diabetes mellitus

Metabolism: Clinical and Experimental
Naohiko TakahashiHironobu Yoshimatsu

Abstract

Urinary albumin excretion/microalbuminuria and cardiovascular autonomic dysfunction are associated with high mortality in type 2 diabetic patients. We tested the hypothesis that the presence of microalbuminuria would correlate with cardiovascular autonomic dysfunction and insulin resistance in type 2 diabetic patients. The study group consisted of 15 Japanese patients with type 2 diabetes and microalbuminuria (age: 56 +/- 10 years, mean +/- SD). The control group consisted of 19 age-matched patients with normalbuminuria (56 +/- 7 years). Cardiovascular autonomic function was assessed by baroreflex sensitivity (BRS), heart rate variability, plasma norepinephrine concentration, and cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy. BRS was lower in the microalbuminuria group than in the normalbuminuria group (P < .05). Early and delayed 123I-MIBG myocardial uptake values were lower (P < .05 and P < .005, respectively) and the percent washout rate of 123I-MIBG was higher (P < .0005) in the microalbuminuria group than in the normalbuminuria group. Fasting plasma glucose (P < .05) and insulin concentrations (P < .05), and the homeostasis model assessment (HOMA) index (P < .01) were higher in the microalbuminuria group than in...Continue Reading

References

Jun 1, 1990·Diabetes Care·R W Stout
Feb 1, 1996·Diabetes Research and Clinical Practice·D J Ewing
Nov 5, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M K RutterS M Marshall
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A GottsäterG Sundkvist
Aug 13, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C F ClarkeG A Werther
Sep 11, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D Muhr-BeckerO Schnell
Jul 14, 2001·Journal of the American College of Cardiology·N TakahashiT Sakata
Sep 28, 2001·Diabetes Care·Z T Bloomgarden
Feb 6, 2002·Circulation·Guido ArcaroRiccardo C Bonadonna
Jun 12, 2003·Journal of the American College of Cardiology·Jennifer E LiuRichard B Devereux
Jun 26, 2003·Journal of Internal Medicine·C E Mogensen
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Futoshi AnanHironobu Yoshimatsu

❮ Previous
Next ❯

Citations

Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Futoshi AnanHironobu Yoshimatsu
Jun 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Matthias Weck
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Vincent Rigalleau, Henri Gin
Dec 9, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A A Leite, O J M Nascimento
Dec 23, 2011·American Journal of Physiology. Cell Physiology·Jinxu LiuYu-Long Li
May 11, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Norihiro OkadaHironobu Yoshimatsu
Apr 12, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Kunio YufuTetsunori Saikawa
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Futoshi AnanHironobu Yoshimatsu
Sep 6, 2005·Journal of Epidemiology·Shinichi TaniharaUNKNOWN NIPPON DATA Research Group
Apr 22, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sung Keun ParkHyun Pyo Hong
Dec 24, 2005·Kidney International·L HenarehS Agewall
Jan 17, 2007·Metabolism: Clinical and Experimental·Futoshi AnanHironobu Yoshimatsu
Jun 21, 2005·International Journal of Clinical Practice·G I VarugheseG Y H Lip
Jun 27, 2006·European Journal of Clinical Investigation·F AnanH Yoshimatsu
Aug 19, 2007·European Journal of Clinical Investigation·F AnanH Yoshimatsu
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·A EsteghamatiM Abbasi
Apr 15, 2011·Metabolism: Clinical and Experimental·Christina VoulgariNicholas Tentolouris
Oct 14, 2020·Aging Cell·Benoit R GauthierAlejandro Martin-Montalvo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.