Feb 9, 1984

Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes

The New England Journal of Medicine
C E Mogensen

Abstract

We studied whether microalbuminuria (30 to 140 micrograms of albumin per milliliter) would predict the later development of increased proteinuria and early mortality in Type II diabetics. During 1973, morning urine specimens of diabetic clinic patients 50 to 75 years of age whose disease had been diagnosed the age of 45 were examined for albumin level by radioimmunoassay. Seventy-six patients with albumin concentrations of 30 to 140 micrograms per milliliter were identified for long-term follow-up. They were compared with normal controls, diabetic patients with lower albumin concentrations (75 patients with concentrations less than 15 micrograms per milliliter and 53 with concentrations of 16 to 29 micrograms per milliliter), and 28 diabetic patients with higher concentrations (greater than 140). Age, duration of diabetes, treatment method, fasting blood glucose level, blood pressure, height, and weight were determined for the four diabetic groups. After nine years the group with albumin concentrations of 30 to 140 micrograms per milliliter was more likely to have clinically detectable proteinuria (greater than 400 micrograms per milliliter) than were the groups with lower concentrations. Mortality was 148 per cent higher in th...Continue Reading

  • References13
  • Citations885

References

  • References13
  • Citations885

Citations

Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Urine
Albuminuria
Fasting Blood Glucose Measurement
ALB
Proteinuria
Nodular Glomerulosclerosis
Blood Pressure
Proteinuria of Undiagnosed Cause
ALB gene

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