Microanatomic features of pancreatic islets and immunolocalization of glucose transporters in tissues of llamas and alpacas

American Journal of Veterinary Research
Christopher K CebraKay A Fischer

Abstract

To describe the microanatomic features of pancreatic islets and the immunohistochemical distribution of glucose transporter (GLUT) molecules in the pancreas and other tissues of New World camelids. 7 healthy adult New World camelids, 2 neonatal camelids with developmental skeletal abnormalities, and 2 BALB/c mice. Samples of pancreas, liver, skeletal muscle, mammary gland, brain, and adipose tissue were collected postmortem from camelids and mice. Pancreatic tissue sections from camelids were assessed microscopically. Sections of all tissues from camelids and mice (positive control specimens) were examined after staining with antibodies against GLUT-1, -2, -3, and -4 molecules. In camelids, pancreatic islets were prominent and lacked connective tissue capsules. Numerous individual endocrine-type cells were visible distant from the islets. Findings in neonatal and adult tissues were similar; however, the former appeared to have more non-islet-associated endocrine cells. Via immunostaining, GLUT-2 molecules were detected on pancreatic endocrine cells and hepatocytes in camelids, GLUT-1 molecules were detected on the capillary endothelium of the CNS, GLUT-3 molecules were detected throughout the gray matter, and GLUT-4 molecules w...Continue Reading

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Citations

Jul 2, 2009·Journal of Veterinary Internal Medicine·C C Smith, C K Cebra
Mar 23, 2011·Journal of Veterinary Internal Medicine·E R S CloreD E Anderson
Oct 31, 2013·American Journal of Veterinary Research·Courtney C SmithBernadette V Stang
May 23, 2009·The Veterinary Clinics of North America. Food Animal Practice·Christopher K Cebra

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