PMID: 11898398Mar 20, 2002Paper

Microarray analysis of B-cell stimulation

Vitamins and Hormones
J Ollila, Mauno Vihinen

Abstract

B-cell development to antibody-producing plasma cells requires the concerted function of a large number of genes and proteins. Genome-level expression profiling during human B-cell maturation was studied in anti-immunoglobulin M-stimulated Ramos cells. cDNA microarrays were used to follow changes in the transcriptome over several days. Close to 1500 genes had significantly altered expression at least at one time point. The genes were organized into clusters based on expression profiles and were further characterized based on the functions of the coded proteins. Several groups of genes important for B cells were analyzed. Here we concentrate on genes involved in signal transduction and cytokines and their receptors. The results provide knowledge on the development of humoral immunity. Several new genes were found to be essential for B-cell development. They can be used as targets for research and possibly for drug development.

Citations

Jul 9, 2003·Genes and Immunity·J Ollila, M Vihinen
Nov 13, 2003·Current Opinion in Allergy and Clinical Immunology·Haiying QinDavid L Nelson
Sep 2, 2006·Proteomics·Johanna M SalonenMauno Vihinen
Nov 10, 2013·PloS One·Johanna SalonenMauno Vihinen

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.