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Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint

The Journal of Pharmacology and Experimental Therapeutics

Dec 27, 2005

James Franklin DillmanCarol L K Sabourin

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Abstract

Bis-(2-chloroethyl) sulfide (sulfur mustard; SM) is a potent alkylating agent. Three treatment compounds have been shown to limit SM damage in the mouse ear vesicant model: dimercaprol, octyl homovanillamide, and indomethacin. Microarrays were used to determine gene expression profiles ...read more

Mentioned in this Paper

External Ear
Microarray Analysis
Sulfides
Administration, Topical
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression
Psoriazin
Indomethacin
Gene Expression Profiling
Mustard Gas
Paper Details
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Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint

The Journal of Pharmacology and Experimental Therapeutics

Dec 27, 2005

James Franklin DillmanCarol L K Sabourin

PMID: 16377760

DOI: 10.1124/jpet.105.097014

Abstract

Bis-(2-chloroethyl) sulfide (sulfur mustard; SM) is a potent alkylating agent. Three treatment compounds have been shown to limit SM damage in the mouse ear vesicant model: dimercaprol, octyl homovanillamide, and indomethacin. Microarrays were used to determine gene expression profiles ...read more

Mentioned in this Paper

External Ear
Microarray Analysis
Sulfides
Administration, Topical
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression
Psoriazin
Indomethacin
Gene Expression Profiling
Mustard Gas

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of Biochemical and Molecular Toxicology

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Paper Details
References
  • References
  • Citations14
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations14
12

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