Microarray analysis of transcription factor gene expression in melatonin-treated human peripheral blood mononuclear cells

Journal of Pineal Research
Eunyoung HaHyung Hwan Baik

Abstract

The existence of specific melatonin-binding sites in lymphoid cells led to the discovery of signal transduction pathway for melatonin in human lymphocytes and immunomodulatory role of melatonin in immune cells. In recent years, transcriptional regulation of melatonin on various transcription factors has been demonstrated. Therefore, this study was designed to assess by cDNA microarray analysis the regulatory effects of melatonin on transcription factors in human peripheral blood mononuclear cells (PBMCs). Forty-six genes were upregulated and 23 were downregulated more than twofold in melatonin-treated PBMCs. Of the more than twofold upregulated transcription factor genes, homeo box A4 (HOXA4), forkhead box O1A (FOXO1A), transcription elongation factor B (SIII), polypeptide 3 (TCEB3), and peroxisome proliferative activated receptor delta (PPARD) were identified. Of the more than twofold downregulated genes, PHD finger protein 15 (PHF15) and zinc finger protein 33a (ZNF33A) were identified. In summary, identification of these genes by cDNA microarray analysis in response to melatonin administration may provide a foundation for further studies on the function of melatonin in human PBMCs.

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Citations

Jun 17, 2008·General and Comparative Endocrinology·Sandrine SauzetJack Falcón
Jul 25, 2007·Journal of Pineal Research·Cyril D TomaTheresia Thalhammer
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Dong HuangZhi-Qiang Li
Mar 31, 2015·Obstetrics and Gynecology International·F J ValenzuelaC Lagunas
Feb 6, 2017·Journal of Pineal Research·Wenkai RenYulong Yin
Sep 8, 2017·International Journal of Molecular Sciences·Federica Lo SardoSabrina Strano
Sep 23, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Paula R PedreiraGuillermo M Albaiceta
May 14, 2021·Frontiers in Pharmacology·Monika Dmitrzak-WeglarzJoanna Pawlak

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