Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Rachael ThomasM Breen

Abstract

Injection-site-associated sarcomas (ISAS), commonly arising at the site of routine vaccine administration, afflict as many as 22,000 domestic cats annually in the USA. These tumors are typically more aggressive and prone to recurrence than spontaneous sarcomas (non-ISAS), generally receiving a poorer long-term prognosis and warranting a more aggressive therapeutic approach. Although certain clinical and histological factors are highly suggestive of ISAS, timely diagnosis and optimal clinical management may be hindered by the absence of definitive markers that can distinguish between tumors with underlying injection-related etiology and their spontaneous counterpart. Specific nonrandom chromosome copy number aberrations (CNAs) have been associated with the clinical behavior of a vast spectrum of human tumors, providing an extensive resource of potential diagnostic and prognostic biomarkers. Although similar principles are now being applied with great success in other species, their relevance to feline molecular oncology has not yet been investigated in any detail. We report the construction of a genomic microarray platform for detection of recurrent CNAs in feline tumors through cytogenetic assignment of 210 large-insert DNA clo...Continue Reading

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Citations

Apr 14, 2016·The Veterinary Clinics of North America. Small Animal Practice·Elizabeth A Ballegeer
Jun 15, 2005·BMC Bioinformatics·Chad L MyersOlga G Troyanskaya
Jan 9, 2013·Journal of Feline Medicine and Surgery·Olga TravettiJimmy H Saunders
Aug 16, 2016·Veterinary Sciences·Filomena AdegaRaquel Chaves
Aug 31, 2015·Veterinary Sciences·Rachael Thomas

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