Microarray expression profile analysis of long noncoding RNAs in premature brain injury: A novel point of view

Neuroscience
Rujuan ChenXiaojie Lin

Abstract

Long noncoding RNAs (lncRNAs) are abundant in the central nervous system and have a key role in brain function as well as many neurological disorders. However, the regulatory function of lncRNAs in the premature brain has not been well studied. This study described the expression profile of lncRNAs in premature mice using microarray technology. 1999 differentially expressed lncRNAs and 955 differentially expressed mRNAs were identified. Gene Ontology (GO) and pathway analysis showed that these lncRNAs were involved in multiple biological processes, including the nervous system development and inflammatory response. Additionally, the lncRNA-mRNA-network and TF-gene-lncRNA-network were constructed to identify core regulatory lncRNAs and transcription factors. The sex-determining region of Y chromosome (SRY) gene may be a key transcription factor that regulates premature brain development and injury. This study for the first time represents an expression profile of differentially expressed lncRNAs in the premature brain and may provide a novel point of view into the mechanisms of premature brain injury.

References

Oct 24, 2000·Biochimica Et Biophysica Acta·E SerflingA Avots
Jun 26, 2003·Nucleic Acids Research·A E KelE Wingender
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jerald P RadichPeter S Linsley
Oct 9, 2007·Nature Genetics·Miguel Angel PujanaMarc Vidal
Oct 10, 2009·Science·Darcie L MooreJeffrey L Goldberg
Feb 11, 2010·Molecular Cancer Research : MCR·Giridhar MudduluruHeike Allgayer
Apr 13, 2010·Brain Research·Irfan A QureshiMark F Mehler
Jul 22, 2010·Nature Reviews. Neuroscience·Anand SwaroopDouglas Forrest
Jul 26, 2011·International Journal of Alzheimer's Disease·Farzaneh ModarresiMiguel A Lopez-Toledano
Jul 30, 2011·Journal of Neurochemistry·Louise RovsingDavid C Klein
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Jin ChewVittorio Gallo
Jul 21, 2012·Nature Reviews. Neuroscience·Irfan A Qureshi, Mark F Mehler
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beata JablonskaVittorio Gallo
Apr 9, 2013·Trends in Genetics : TIG·Shi-Yan NgLawrence W Stanton
Jun 5, 2013·Biological Chemistry·Matthias WeiderMichael Wegner
Feb 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kyung Eun LeeJaesang Kim
Feb 27, 2014·Nature Neuroscience·Natalina SalmasoVittorio Gallo
Mar 13, 2014·Nature Neuroscience·Stephen P J FancyDavid H Rowitch
Aug 20, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas C RobertsMatthew J A Wood
Sep 24, 2014·Nature Reviews. Endocrinology·Stefanie EggersAndrew Sinclair
Jun 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Loyal A GoffJohn L Rinn

❮ Previous
Next ❯

Citations

Sep 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tong LiXinmei Liu
Oct 24, 2018·Frontiers in Neuroscience·Ying ZhangFeng-Xu Yu
Nov 25, 2018·Journal of Clinical Medicine·Young-Kook Kim, Juhyun Song
Jan 12, 2019·Neural Regeneration Research·Li-Xiang YangKun Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.