Microarray gene analysis and expression profiles of Dupuytren's contracture

Annals of Plastic Surgery
Deborah PanDeepak Narayan

Abstract

Dupuytren's disease, although not altogether uncommon, has eluded scientists who have sought to explain the cause of this palmar fibroproliferative disorder. It can lead to severe limitations of hand function if left untreated. This study is the first broad genetic survey using microarray technology to find gene products that are overexpressed or underexpressed in diseased tissues. The authors found 23 genes with levels that differ consistently from control levels. Nine were selected for further verification using reverse transcription-polymerase chain reaction. These genes hold potential promise in explaining some of the demographic trends seen with disease, such as correlation with alcoholism and the striking predisposition for the male gender.

References

Apr 1, 1990·The Australian and New Zealand Journal of Surgery·G A Murrell, J T Hueston
Jul 1, 1997·Protein Science : a Publication of the Protein Society·T L HoltetM Etzerodt
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M E CalhounM Jucker
Jul 7, 2000·Plastic and Reconstructive Surgery·J D Saar, P C Grothaus
May 30, 2001·Neuroscience Research·T Kato
Jun 5, 2001·Nature Reviews. Genetics·J Quackenbush
Jun 5, 2001·Nature Reviews. Neuroscience·D H Geschwind

❮ Previous
Next ❯

Citations

Sep 2, 2008·Archives of Orthopaedic and Trauma Surgery·Dietmar UlrichNorbert Pallua
Aug 3, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Neda MosakhaniSakari Knuutila
Sep 29, 2011·Arthritis Research & Therapy·Samrina RehmanHans V Westerhoff
Oct 17, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tsuyoshi TajikaKenji Takagishi
Feb 3, 2012·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Natasha E Picardo, Wasim S Khan
Sep 13, 2016·Current Molecular Biology Reports·S KarkampounaMarianna Kruithof-de Julio
Nov 13, 2007·The Journal of Surgical Research·Minna ForsmanJorma Ryhänen
Aug 5, 2016·JBJS Reviews·Apostolos D Prodromidis, Charalambos P Charalambous
Jan 11, 2013·The Journal of Hand Surgery, European Volume·A ZylukP Puchalski
Sep 12, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ivana RatkajSandra Kraljević Pavelić
Aug 19, 2007·Plastic and Reconstructive Surgery·Robert B ShawJames Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.