PMID: 9192237May 1, 1997Paper

Microatelectasis in patients with secundum atrial septal defect and its relation to pulmonary hypertension

Japanese Circulation Journal
S YamakiT Takahashi

Abstract

In patients with secundum atrial septal defect, pulmonary hypertension appears to be attributable to microatelectasis of the lung. To confirm this hypothesis, pulmonary arteries in surgical biopsy specimens from 72 patients with atrial septal defect and pulmonary hypertension were subjected to morphometric examination. Thirty eight of the 72 patients (53%) were found to have microatelectasis of the lung, which suggests that an even higher frequency would have been found if the entire organ had been examined. Atelectatic changes were found in 21 of 39 patients with plexogenic pulmonary arteriopathy (54%), 8 of 15 with musculoelastosis (53%), and 9 of 13 with both of these lesions (69%). No such changes were observed in 5 patients with atrial septal defect who showed thromboembolism-type lesions of the pulmonary arteries. On the other hand, microatelectasis was not observed in another 5 patients with atrial septal defect who did not exhibit pulmonary hypertension. The medial smooth muscles of pulmonary arteries in atelectatic areas were thicker (16.4 +/- 4.0 microns) than those in non-atelectatic areas (10.3 +/- 3.3 microns). The index of pulmonary vascular disease was not significantly different between atelectatic (2.0 +/- 0.6)...Continue Reading

Citations

Jun 13, 2006·Critical Care : the Official Journal of the Critical Care Forum·Dinis Reis MirandaDiederik Gommers
Jul 8, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Hisao ItoTadashi Ishibashi
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoki OhashiShigeo Yamaki
Apr 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Dinis Reis MirandaBurkhard Lachmann
Aug 26, 2006·Critical Care Medicine·Dinis Reis MirandaDiederik Gommers
Apr 23, 2005·Cardiology in the Young·Henrik BrunErik Thaulow

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