Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function

Molecular Immunology
C N CastroT Sparwasser

Abstract

During the past two decades, a growing interest surrounding the interaction between microbe-associated molecular patterns (MAMPs) and pattern recognition receptors has occurred. This attention is now driven alongside bacterial-derived metabolites, which impact immune cell differentiation and function. Hence, this review introduces the term meta-MAMP as a means to classify the microbial derived-metabolites, which influence the immune response by affecting specific cellular processes. We discuss two prominent examples of meta-MAMPs: the first, rapamycin (isolated from Streptomyces), was discovered in the 1970s and since then has been thoroughly studied. The second, soraphen A (isolated from Myxobacteria), was discovered in the early 1990s but only recently identified as a promising immunomodulator. Both meta-MAMPs are similar in their remarkable capacity to modulate T cell fate by targeting key metabolic pathways triggered upon T cell activation. In this context, we highlight the progress made in the field of immunometabolism and the possibility of modulating metabolic pathways such as cellular fatty acid metabolism as a strategy for immunomodulation. We focus on the use of microbial metabolites as auspicious agents for T cell fa...Continue Reading

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Citations

Mar 22, 2016·International Journal of Medical Microbiology : IJMM·Claudia GüntherJan Wehkamp
Aug 27, 2016·Immunology and Cell Biology·Jenny FreitagTim Sparwasser
Mar 24, 2017·Nature Reviews. Rheumatology·Timo GaberFrank Buttgereit
Dec 3, 2016·Natural Product Reports·J HerrmannR Müller
Oct 4, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Vadim PivnioukDonata Vercelli
Dec 7, 2016·Seminars in Immunopathology·Lucía MinarrietaLuciana Berod
Jan 29, 2019·Frontiers in Pharmacology·Paulo José BassoHelioswilton Sales-Campos
May 15, 2020·The Journal of Allergy and Clinical Immunology·Guilhermina M CarricheTim Sparwasser
May 11, 2021·The Journal of Allergy and Clinical Immunology·Luís AlmeidaTim Sparwasser
Aug 29, 2021·Pharmaceutics·Mudasir Ahmad BhatArif Tasleem Jan

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