Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa

Microbiology
Willem M de Vos

Abstract

Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface. Since its recent discovery, A. muciniphila has increasingly been studied and recognized as a true intestinal symbiont promoting beneficial interactions in the intestinal tract.

References

Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Mar 23, 2012·The ISME Journal·Clara Belzer, Willem M de Vos

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Citations

Apr 11, 2018·Nature Reviews. Clinical Oncology·Bertrand RoutyGuido Kroemer
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pekka MäättänenPhilip M Sherman
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Dec 29, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Brian BicknellHosen Kiat

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