Microbe Profile: Corynebacterium diphtheriae - an old foe always ready to seize opportunity

Microbiology
Paul A Hoskisson

Abstract

Corynebacterium diphtheriae is a globally important Gram-positive aerobic Actinobacterium capable of causing the toxin-mediated disease, diphtheria. Diphtheria was a major cause of childhood mortality prior to the introduction of the toxoid vaccine, yet it is capable of rapid resurgence following the breakdown of healthcare provision, vaccination or displacement of people. The mechanism and treatment of toxin-mediated disease is well understood, however there are key gaps in our knowledge on the basic biology of C. diphtheriae particularly relating to host colonisation, the nature of asymptomatic carriage, population genomics and host adaptation.

References

Nov 7, 2003·Nucleic Acids Research·A M Cerdeño-TárragaJ Parkhill
Apr 28, 2009·Vaccine·Isabelle BonmarinDaniel Levy-Bruhl
Nov 10, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vartul SangalPaul A Hoskisson
Jun 15, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vartul Sangal, Paul A Hoskisson

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Citations

May 1, 2021·Microorganisms·Takashi HamabataKeigo Shibayama
Aug 18, 2021·Microbiology·Gavin H Thomas

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