Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change

Trends in Neurosciences
Jürgen G Haas, Richard Lathe

Abstract

Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.

Citations

Jan 9, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Richard LatheRuth Itzhaki
May 2, 2020·Journal of Neuropathology and Experimental Neurology·Peter T NelsonYuriko Katsumata
Aug 6, 2020·Neurology. Genetics·Chen ZhaoMitchell S V Elkind
May 22, 2019·Expert Review of Neurotherapeutics·Francesco PanzaBruno Pietro Imbimbo
Mar 8, 2020·Journal of Alzheimer's Disease : JAD·Masafumi Ihara, Satoshi Saito
Sep 4, 2019·Ageing Research Reviews·Praveen BathiniLavinia Alberi Auber
Jun 10, 2021·Antiviral Research·Patricia LlorenteMaria J Bullido

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