Microbial amino acid synthesis and utilization in rats: the role of coprophagy

The British Journal of Nutrition
David TorrallardonaMalcolm F Fuller

Abstract

Four rats were housed in cages with mesh floors; another four rats were housed in tubular anticoprophagy cages, in which they could not turn round to reach their own faeces. Both groups were fed for 6 d on a low-protein diet containing fermentable carbohydrates and 15NH4Cl. At the end of the experiment the rats were killed and their carcasses were homogenized, lysine was isolated by ion-exchange chromatography and its 15N enrichment measured by isotope-ratio mass spectrometry. The 15N enrichment in the lysine of the microbial fraction of faeces and the total amount of lysine in the body were also determined in order to estimate the amount of microbial lysine absorbed. The 15N enrichment in body lysine of non-coprophagic rats was not different from that previously measured in rats given unlabelled NH4Cl, but in coprophagic rats it was significantly higher. The daily absorption of microbial lysine by the coprophagic rats accounted for 20.7 (SE 2.55) mg/kg body weight0-75, but was only 0.5 (SE 1.04) mg/kg body weight0-75 for the non-coprophagic rats. This value was not significantly different from zero. The utilization of microbial amino acids via coprophagy resulted in a higher weight gain (adjusted for intake) in the coprophagic...Continue Reading

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Citations

Nov 10, 2005·The British Journal of Nutrition·Alvaro BelenguerEric Milne
Nov 10, 2005·The British Journal of Nutrition·Cornelia C Metges, Klaus J Petzke
Jun 1, 2005·Nutrition Research Reviews·Gavin S Stewart, Craig P Smith
Aug 26, 1998·Annual Review of Nutrition·M F Fuller, P J Reeds
Mar 21, 2016·Annals of the New York Academy of Sciences·R Scott McIsaacRochelle Buffenstein
Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Apr 4, 2003·The Journal of Nutrition·David TorrallardonaMalcolm F Fuller
Mar 15, 2005·International Journal of Food Sciences and Nutrition·Alan A JacksonStephen A Wootton
Nov 27, 2002·The American Journal of Clinical Nutrition·Gunda BackesCornelia C Metges
Jun 18, 2017·Frontiers in Endocrinology·Hartmut H Glossmann, Oliver M D Lutz
Oct 2, 2020·The Journal of Nutrition·Dwight E Matthews
Jun 27, 2000·The Journal of Nutrition·C C Metges
May 22, 2007·The Journal of Nutrition·Ronald O BallPaul B Pencharz

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