Microbial and metabolic multi-omic correlations in systemic sclerosis patients

Annals of the New York Academy of Sciences
Chiara BellocchiLorenzo Beretta

Abstract

Intestinal microbiota has been associated with systemic autoimmune diseases, yet the functional consequences of these associations are elusive. We characterized the fecal microbiota (16S rRNA gene amplification and sequencing) and the plasma metabolome (high-performance liquid chromatography coupled to mass spectrometry) in 59 patients with systemic sclerosis (SSc) and 28 healthy controls (HCs). Microbial and metabolic data were cross-correlated to find meaningful associations after extensive data mining analysis and internal validation. Our data show that a reduced model of nine bacteria is capable of differentiating HCs from SSc patients. SSc gut microbiota is characterized by a reduction in protective butyrate-producing bacteria and by an increase in proinflammatory noxious genera, especially Desulfovibrio. From the metabolic point of view, a multivariate model with 17 metabolite intermediates well distinguished cases from controls. The most interesting peaks we found were identified as glycerophospholipid metabolites and benzene derivatives. The microbial and metabolic data showed significant interactions between Desulfovibrio and alpha-N-phenylacetyl-l-glutamine and 2,4-dinitrobenzenesulfonic acid. Our data suggest that in...Continue Reading

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Citations

Aug 8, 2019·Current Opinion in Rheumatology·Zsuzsanna H McMahan
Sep 30, 2020·Journal of Cutaneous Medicine and Surgery·Lydia OucheneElena Netchiporouk
Jun 27, 2018·Current Rheumatology Reports·Chiara Bellocchi, Elizabeth R Volkmann
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Aug 28, 2019·Journal of Clinical Medicine·Chiara BellocchiLorenzo Beretta
Apr 4, 2021·International Journal of Molecular Sciences·Hee Jin ParkSang-Il Lee
Apr 15, 2021·Best Practice & Research. Clinical Rheumatology·Tze Chin TanAndrea Hsiu Ling Low
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Sep 7, 2021·Clinical Reviews in Allergy & Immunology·Marie Elise TruchetetCarlo Chizzolini
Mar 19, 2021·Rheumatology·Shannon TeawMichelle Cheng

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