Microbial approaches for targeting antibiotic-resistant bacteria

Microbial Biotechnology
Wing Fei Wong, Marina Santiago

Abstract

Antibiotic resistant bacterial infections are a global public health challenge that has been increasing in severity and scope for the last few decades. Without creative solutions to this problem, treatment of injuries and infections will become progressively more challenging. A better understanding of the human microbiome has led to a new appreciation for the role commensal microbes play in protecting us from pathogens, especially in the gut. Antibiotics lead to disruption of the gut microbial ecosystem, enabling colonization by antibiotic resistant bacterial pathogens. Many different lines of research have identified specific bacterial taxa and mechanisms that play a role in colonization resistance, and these lines of research may one day lead to microbial therapeutics targeting antibiotic resistant bacteria. Here, we discuss a few of these strategies and the challenges they will need to overcome in order to become an effective therapeutic.

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Related Concepts

Metazoa
Bacteriocidal Agents
Bacterial Infections
Antibiotic Resistance, Bacterial
Microbiota (plant)
Antibiotics
Bacterial Infections
Research
Poisoning/Injury
Gut

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