Microbial biomarkers for immune checkpoint blockade therapy against cancer

Journal of Gastroenterology
Keishi Adachi, Koji Tamada

Abstract

Three major standard treatments, i.e., surgery, chemotherapy, and radiotherapy, were traditionally applied to the treatment of cancer and saved many patients. Meanwhile, clinical studies as well as basic research of immunotherapy are being actively conducted for intractable or advanced malignancies that cannot be cured by the conventional standard treatments. Remarkable therapeutic efficacies have been recently reported in clinical trials on some cancer types, and immunotherapy is now being recognized as the "fourth" standard therapy against cancer. In particular, immune checkpoint inhibitor therapy (ICI) has demonstrated the effectiveness of immunotherapy through large-scale randomized clinical trials, leading to the paradigm-shift in cancer treatment. Immune checkpoint molecules transduce co-inhibitory signals to immunocompetent cells including T cells, and crucially contribute to the formation of an immunosuppressive microenvironment in tumor tissues, which intrinsically confers the treatment resistance. Programmed death-1 (PD-1, CD279) is one of the typical immune checkpoint molecules. Anti-tumor therapies targeting PD-1 and its ligands had been developed and approved in many countries, and various studies utilizing clinica...Continue Reading

References

Mar 22, 1996·Science·D R LeachJ P Allison
Aug 11, 1998·Immunity·S G WardJ Westwick
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Jul 14, 2001·Science·B PulendranJ Banchereau
Apr 26, 2002·Current Opinion in Immunology·Gregory M Barton, Ruslan Medzhitov
Apr 30, 2003·The Journal of Experimental Medicine·Shengdian WangLieping Chen
Jan 31, 2004·Seminars in Immunology·Chandrashekhar Pasare, Ruslan Medzhitov
Jun 14, 2005·Current Opinion in Immunology·Taro Kawai, Shizuo Akira
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jan 15, 2010·International Journal of Food Microbiology·Patricia LópezAna Suárez
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Feb 5, 2011·Seminars in Immunology·Koji AtarashiKenya Honda
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Jul 31, 2012·Immunity·Jeremy P McAleer, Jay K Kolls
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jul 23, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher J Nirschl, Charles G Drake
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick A OttCaroline Robert
Mar 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lidia RobertAntoni Ribas
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
May 30, 2014·Science Translational Medicine·Edward ChaLawrence Fong
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A PostowJedd D Wolchok
Feb 20, 2015·Molecular Cancer Therapeutics·Sandip Pravin Patel, Razelle Kurzrock
Apr 1, 2015·Clinical Therapeutics·Kathleen M MahoneyDavid F McDermott
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
May 15, 2015·Nature·Stefani SprangerThomas F Gajewski
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.