Microbial colonization and atopic dermatitis

Current Opinion in Allergy and Clinical Immunology
Antonie RollPeter Schmid-Grendelmeier

Abstract

Atopic dermatitis is a chronic relapsing, pruritic inflammation of the skin, affecting 10-20% of children and 1-3% adults worldwide, with increasing prevalence in highly industrialized countries. Here we review relevant studies, published since June 2002, about immunological triggers in atopic dermatitis, with emphasis on the role of microbial colonization. During the past 2 years there has been considerable interest in the mechanisms and trigger factors underlying the increased microbial colonization of atopic skin. Staphylococcus aureus appears to play a significant role as it leads to a worsening of disease severity by producing superantigens that induce a strong proliferation of T cells and favour a T helper type 2-like cytokine profile. In addition, different Malassezia species seem to elicit and maintain skin inflammation after sensitization, but the precise immunological pathway has not yet been described. All these microorganisms are not only perceived as aetiological factors but also as agents responsible either for sustained disease activity or resistance to therapy by modulation of the immune response. New insights into the important role of microorganisms and their key immunomodulatory pathways in atopic dermatitis ...Continue Reading

References

Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
May 1, 1996·Journal of the American Academy of Dermatology·F Schultz LarsenA Svensson
Oct 1, 1996·The British Journal of Dermatology·M GfesserJ Ring
Aug 15, 1997·Microscopy Research and Technique·M Fartasch
Jul 24, 1998·Biochemical and Biophysical Research Communications·H YasuedaK Akiyama
Feb 16, 1999·The Journal of Investigative Dermatology·I StricklandD Y Leung
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·D Y Leung
Oct 16, 1999·The Journal of Allergy and Clinical Immunology·B FischerA Helbling
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·R BunikowskiH Renz
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BuentkeA Scheynius
May 12, 2001·The Journal of Investigative Dermatology·S H ChoD Y Leung
Jul 14, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·O Bäck, J Bartosik
Jul 14, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·W Aberer, B Kränke
Oct 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BuentkeA Scheynius
Mar 19, 2002·The Journal of Allergy and Clinical Immunology·Sakari ReitamoUNKNOWN European /Canadian Tacrolimus Ointment Study Group
Mar 19, 2002·The Journal of Allergy and Clinical Immunology·Sakari ReitamoUNKNOWN European Tacrolimus Ointment Study Group
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Kristian ReichChristine Neumann
Apr 30, 2002·International Archives of Allergy and Immunology·Annika ScheyniusMaria Tengvall Linder
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N KandaS Watanabe
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Mar 26, 2003·The British Journal of Dermatology·C JohanssonM Tengvall Linder
Jul 2, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Anke GaugerDietrich Abeck
Feb 3, 2004·Clinical Reviews in Allergy & Immunology·Maria Yazdanbakhsh, Paolo M Matricardi
Feb 14, 2004·Archives of Dermatological Research·Giovanna DonnarummaAdone Baroni
Apr 13, 2004·International Journal of Epidemiology·Sam GibbsRichard Reading
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Liang-Shiou OuDonald Y M Leung

❮ Previous
Next ❯

Citations

Jun 30, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·W WitteU Jappe
Sep 8, 2012·International Archives of Occupational and Environmental Health·Shigekazu UkawaReiko Kishi
Apr 15, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Mingming WangDaliang Zhang
Jun 28, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Giuseppe StincoFrancesca Valent
Jan 6, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luigia BrunettiLucio Armenio
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Peter D ArkwrightUNKNOWN Atopic Dermatitis Working Group of the Allergic Skin Diseases Committee of the AAAAI
Oct 17, 2012·Seminars in Cutaneous Medicine and Surgery·Charles N EllisLawrence F Eichenfield
Sep 30, 2006·The Journal of Investigative Dermatology·Susanne StemmlerSabine Hoffjan
Sep 27, 2008·The Journal of Investigative Dermatology·Ikue Nemoto-HasebeHiroshi Shimizu
Jun 15, 2005·Dermatologic Therapy·Nina MirchandaniNanette B Silverberg
Mar 18, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A D LeungA H Liu
Feb 1, 2013·The British Journal of Dermatology·S G Danby, M J Cork
Jun 24, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·A Katsarou, Mc Armenaka
Dec 16, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K ReginaldR Valenta
Aug 21, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Ching-Shen TangWen-Tsung Lo
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Eniko SonkolyBernhard Homey
Oct 30, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V van DrongelenA El Ghalbzouri
Jul 26, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Akihiko TanakaHironori Sagara
Aug 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Allison L Goddard, Peter A Lio
Nov 2, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hesham A NadaRabee Abu Baker
Jun 14, 2016·BioMed Research International·Ieva SauliteUlrike Wehkamp
Aug 16, 2016·Pediatric Annals·Katherine Grey, Sheilagh Maguiness
Nov 8, 2014·Asia Pacific Allergy·Melissa Lee, Hugo Van Bever
Jun 5, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas VolzTilo Biedermann
Jul 21, 2011·Current Opinion in Allergy and Clinical Immunology·Adriano MariClaudia Alessandri
Jan 1, 2015·Children·Neema IzadiJonathan S Tam
Mar 13, 2019·Current Infectious Disease Reports·J Chase McNeil, Stephanie A Fritz
Apr 11, 2019·Pediatric Dermatology·Jeena K SandhuApril W Armstrong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

© 2021 Meta ULC. All rights reserved