Microbial contamination of nebulization solution and its measures

Biological & Pharmaceutical Bulletin
Shigeharu OieAkira Kamiya

Abstract

We evaluated the microbial contamination of nebulization solutions in medication cups from a total of 76 ultrasonic nebulizers in use in 10 hospitals. In addition, an interview survey was given to nurses to evaluate the disinfection methods of these ultrasonic nebulizers. Of a total of 76 nebulization solution samples, 11 (14.5%) were contaminated with 10-10(2) colony-forming units (CFU)/ml and 9 (11.8%) with 10(3)-10(5) CFU/ml. The major contaminants were glucose non-fermentative bacilli such as Burkholderia cepacia, CDC gr.IV C-2, and Sphingomonas paucimobilis. Comparison of microbial contamination between the frequencies of disinfection showed a significantly lower number of contaminated samples when the cups were disinfected once daily than when disinfected once at intervals of 2-7 d (p=0.00037). In addition, comparison between the presence and absence of preservatives contained in the nebulization solution showed a significantly lower number of contaminated samples in the presence, rather than in the absence, of preservatives (p=0.00001). These results show that disinfection of ultrasonic nebulizers at 24-h intervals is desirable. In particular, when nebulization solutions not containing preservatives are used, disinfectio...Continue Reading

References

Jan 1, 1976·Journal of Clinical Microbiology·S M GelbartH B Greenlee
Sep 1, 1987·The Journal of Hospital Infection·M J Botman, R A de Krieger
Oct 1, 1968·Annals of Internal Medicine·R E RingroseE R Rhoades
Jul 1, 1970·Annals of Internal Medicine·C V SandersJ P Sanford
Nov 1, 1996·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A C ReboliT L Stull
May 9, 2003·Biological & Pharmaceutical Bulletin·Naoyuki MiyanoAkira Kamiya
Sep 1, 1961·Journal of Pharmaceutical Sciences·D N ENTREKIN

❮ Previous
Next ❯

Citations

Dec 3, 2014·Diagnostic Microbiology and Infectious Disease·Tiziana D'InzeoTeresa Spanu
May 7, 2010·Journal of Clinical Microbiology·Joan-Miquel Balada-LlasatPreeti Pancholi
Jun 1, 2009·Clinical Journal of Gastroenterology·Alberto Di LeoFrancesco Ricci
May 4, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Jiun-Nong LinHsi-Hsun Lin
Oct 22, 2010·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Michel Toussaint, Gregory Reychler
Jun 26, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lamia Djouhri-BouktabJean Michel Brunel
Mar 29, 2016·World Journal of Methodology·Yoko IdaTakashi Watanabe
May 27, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Gregory ReychlerUNKNOWN Belgian CF Physio-Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.