Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences

Trends in Immunology
Roos-Marijn BerbersHelen L Leavis

Abstract

Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets.

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Citations

Oct 7, 2017·Current Allergy and Asthma Reports·Paul J MaglioneCharlotte Cunningham-Rundles
May 18, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Daniel TegtmeyerChristian Klemann
Mar 30, 2018·Frontiers in Microbiology·Maria C OpazoClaudia A Riedel
Jan 11, 2020·Frontiers in Immunology·Jessica D Gereige, Paul J Maglione
Jul 29, 2020·International Journal of Molecular Sciences·Ida Judyta MaleszaPiotr Eder
Sep 18, 2020·Current Opinion in Allergy and Clinical Immunology·Kher Ng, John R Hurst
Feb 13, 2021·International Journal of Molecular Sciences·Riccardo CastagnoliLuigi Daniele Notarangelo
Aug 20, 2021·Frontiers in Immunology·Gilda VarricchiGiuseppe Spadaro
Oct 16, 2021·Current Opinion in Pediatrics·Maryam Ali Al-NesfVidya Mohamed-Ali

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