Jun 28, 2014

Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity

Science
Sergey KryazhimskiyMichael M Desai

Abstract

Epistatic interactions between mutations can make evolutionary trajectories contingent on the chance occurrence of initial mutations. We used experimental evolution in Saccharomyces cerevisiae to quantify this contingency, finding differences in adaptability among 64 closely related genotypes. Despite these differences, sequencing of 104 evolved clones showed that initial genotype did not constrain future mutational trajectories. Instead, reconstructed combinations of mutations revealed a pattern of diminishing-returns epistasis: Beneficial mutations have consistently smaller effects in fitter backgrounds. Taken together, these results show that beneficial mutations affecting a variety of biological processes are globally coupled; they interact strongly, but only through their combined effect on fitness. As a consequence, fitness evolution follows a predictable trajectory even though sequence-level adaptation is stochastic.

  • References28
  • Citations97

References

  • References28
  • Citations97

Mentioned in this Paper

Stochastic Processes
Saccharomyces cerevisiae allergenic extract
In Vitro Molecular Evolution
Sequencing
Genes, Fungal
Genome, Fungal
Sequence Determinations, DNA
Microbial
Genetic Fitness
Molecular Sequence Annotation

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