PMID: 12829278Jun 28, 2003Paper

Microbial ferric iron reductases

FEMS Microbiology Reviews
I SchröderS de Vries


Almost all organisms require iron for enzymes involved in essential cellular reactions. Aerobic microbes living at neutral or alkaline pH encounter poor iron availability due to the insolubility of ferric iron. Assimilatory ferric reductases are essential components of the iron assimilatory pathway that generate the more soluble ferrous iron, which is then incorporated into cellular proteins. Dissimilatory ferric reductases are essential terminal reductases of the iron respiratory pathway in iron-reducing bacteria. While our understanding of dissimilatory ferric reductases is still limited, it is clear that these enzymes are distinct from the assimilatory-type ferric reductases. Research over the last 10 years has revealed that most bacterial assimilatory ferric reductases are flavin reductases, which can serve several physiological roles. This article reviews the physiological function and structure of assimilatory and dissimilatory ferric reductases present in the Bacteria, Archaea and Yeast. Ferric reductases do not form a single family, but appear to be distinct enzymes suggesting that several independent strategies for iron reduction may have evolved.


Jan 1, 1979·Journal of Bacteriology·C D Cox, R Graham
Feb 1, 1977·Journal of Bacteriology·H A Dailey, J Lascelles
Apr 1, 1992·Infection and Immunity·D A PortnoyP Cossart
Aug 15, 1992·Journal of Inorganic Biochemistry·G J AndersonR D Klausner
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A DancisR D Klausner
Jan 1, 1991·Biology of Metals·A E Le Faou, S A Morse
May 1, 1990·Molecular and Cellular Biology·A DancisJ G Barriocanal
Apr 19, 1990·Biochimica Et Biophysica Acta·E LesuisseP Labbe
Jan 1, 1990·Archives of Microbiology·E FischerV Braun
Jan 1, 1989·Biology of Metals·F Hallé, J M Meyer
Jul 1, 1989·Journal of Bacteriology·M Huyer, W J Page
Nov 1, 1987·Journal of General Microbiology·E LesuisseR R Crichton
Sep 1, 1985·Journal of Bacteriology·M D Moody, H A Dailey
Feb 1, 1980·Journal of Bacteriology·J E Arceneaux, B R Byers
Dec 31, 1980·Biochemical and Biophysical Research Communications·J S LodgeB R Byers
Jan 1, 1980·Journal of Bacteriology·C D Cox
Feb 1, 1982·Journal of Bacteriology·J S LodgeB R Byers
Nov 10, 1995·The Journal of Biological Chemistry·J B Neilands
Jan 6, 1995·The Journal of Biological Chemistry·R Hassett, D J Kosman
Jan 1, 1994·Annual Review of Microbiology·M L Guerinot
Jan 20, 1995·The Journal of Biological Chemistry·D M De SilvaJ Kaplan
Jan 1, 1994·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M FontecaveJ L Pierre
Mar 1, 1994·The Journal of Applied Bacteriology·C R Myers, J M Myers
Jan 1, 1993·Annual Review of Microbiology·D R Lovley
Jan 14, 1994·Biochemical and Biophysical Research Communications·M EschenbrennerM Fontecave
Jan 1, 1993·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M T Poch, W Johnson
Feb 1, 1993·European Journal of Biochemistry·J Coves, M Fontecave
Dec 22, 1995·The Journal of Biological Chemistry·F FieschiM Fontecave
Jul 1, 1996·Archives of Microbiology·E Barchini, R E Cowart

❮ Previous
Next ❯


Dec 14, 2005·Current Genetics·Cécile HervéCatherine Boyen
Jul 11, 2006·Parasitology Research·Thomas D Lockwood
Jun 26, 2007·Antonie van Leeuwenhoek·Hyung Soo ParkGerrit Voordouw
Sep 24, 2009·Chemical Reviews·Moriah Sandy, Alison Butler
Jan 20, 2004·European Journal of Biochemistry·Jirí MazochJaroslav Turánek
Nov 6, 2010·The Journal of Biological Chemistry·Marcus MiethkeMohamed A Marahiel
May 13, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Norman H Sleep, Dennis K Bird
Sep 21, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Norman H SleepEmily C Pope
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Norman H Sleep
Dec 21, 2010·Applied and Environmental Microbiology·Marcus SchicklbergerJohannes Gescher
Oct 30, 2007·Applied and Environmental Microbiology·Rachel A CrossleyNicholas J Walton
Sep 25, 2012·Applied and Environmental Microbiology·Nicholas B JusticeJillian F Banfield
Sep 13, 2011·Applied and Environmental Microbiology·K C WrightonJ D Coates
Dec 2, 2009·Journal of Bacteriology·Michelle B RyndakG Marcela Rodriguez
Jul 1, 2008·Journal of Bacteriology·Alexandra R MeyShelley M Payne
Oct 19, 2010·Journal of Bacteriology·Christopher M Jones, Michael Niederweis
Dec 31, 2008·Journal of Bacteriology·Jinki YeomWoojun Park
Jun 28, 2011·Journal of Bacteriology·Sandra K Small, Mark R O'Brian
Jul 3, 2004·Journal of Bacteriology·Kiran PalyadaAlain Stintzi
Sep 7, 2007·Microbiology and Molecular Biology Reviews : MMBR·Marcus Miethke, Mohamed A Marahiel
Jul 15, 2005·Journal of Nanobiotechnology·Nelson DuránElisa Esposito
Nov 26, 2010·PLoS Neglected Tropical Diseases·Amber GlanfieldMalcolm K Jones
Oct 8, 2011·Bioscience, Biotechnology, and Biochemistry·Emiko Shinagawa
Jun 25, 2014·Applied Microbiology and Biotechnology·Jisun Kim, Woojun Park
Apr 8, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Rosanne E FrederickJennifer L DuBois
Jan 12, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Junichi SatoYouichi Niimura
Oct 22, 2011·Tuberculosis·Sujatha M Santhanagopalan, G Marcela Rodriguez
Aug 28, 2007·FEBS Letters·Manuela BrocoClaudina Rodrigues-Pousada
Dec 20, 2015·FEMS Microbiology Reviews·Cheryl K Y LauHans J Vogel

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Berthold F MatzankeKlaus Hantke
Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Vicki A BamfordKimberly A Watson
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Brian M Hopkinson, François M M Morel
© 2021 Meta ULC. All rights reserved