Microbial Keratitis and Endophthalmitis After the Boston Type 1 Keratoprosthesis

Cornea
Michael D WagonerMark A Greiner

Abstract

To determine the incidence, ocular surface disease associations, microbiological profile, and clinical course of postoperative infections after implantation of the Boston type 1 keratoprosthesis (KPro-1). A retrospective chart review was conducted of all cases of the KPro-1 performed at a tertiary eye care center between January 1, 2008, and December 31, 2014. Seventy-five KPro-1 procedures were included in the analysis. Postoperative infections occurred in 13 eyes (17.3%) with an incidence of 0.064 cases per eye-year. The Kaplan-Meier probability of an infection-free graft was 0.96, 0.90, 0.88, 0.87, and 0.86 at years 1 through 5, respectively. The rate of infections was greater in eyes with ocular surface disease (26.3% vs. 8.1%, P = 0.06), especially in those with a history of chemical or thermal injury or herpes zoster keratopathy (P = 0.001). There were 8 cases (10.7%) of microbial keratitis due to either fungi (5 cases) or bacteria (3 cases). There were 7 cases (9.3%) of endophthalmitis due to bacteria (5 cases) or intraocular extension of fungal keratitis (2 cases). The incidence of microbial keratitis and endophthalmitis was 0.034 and 0.03 cases per eye-year, respectively. Therapeutic management of the infected eyes req...Continue Reading

References

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Sep 24, 2015·Cornea·David L PhillipsMichael D Wagoner

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Citations

Mar 8, 2019·Retina·Ferran VilaplanaRafael I Barraquer
Aug 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yishun GuoBailiang Wang
May 25, 2021·Bioengineering & Translational Medicine·Kunal S ParikhJustin Hanes
Jun 9, 2021·American Journal of Ophthalmology·Pinnita PrabhasawatWarinyupa Pinitpuwadol
Feb 26, 2021·Cornea·Reza GhaffariAnthony J Aldave

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