Microbial modulation of the gut microbiome for treating autoimmune diseases

Expert Review of Gastroenterology & Hepatology
Baskar Balakrishnan, Veena Taneja

Abstract

Many studies have shown the relationship between autoimmune diseases and the gut microbiome in humans: those with autoimmune conditions display gut microbiome dysbiosis. The big question that needs to be addressed is if restoring eubiosis of the gut microbiota can help suppress the autoimmune condition by activating various immune regulatory mechanisms. Inducing these self-healing mechanisms should prolong good health in affected individuals. Area covered: Here, we review the available clinical and preclinical studies that have used selective bacteria for modulating gut microbiota for treating autoimmune diseases. The potential bacterial candidates and their mechanism of action in treating autoimmune diseases will be discussed. We searched for genetically modified and potential probiotics for diseases and discuss the most likely candidates. Expert commentary: To achieve eubiosis, manipulation of the gut microbiota must occur in some form. Several approaches for modulating gut microbiota include prebiotic diets, antimicrobial interventions, fecal microbiota transplants, and selective probiotics. One novel approach showing promising results is the use of selective bacterial candidates to modulate microbial composition. Use of sin...Continue Reading

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Citations

Mar 23, 2019·Military Medicine·Baskar BalakrishnanVeena Taneja
Apr 14, 2019·Microorganisms·Aaron LernerTorsten Matthias
Jul 11, 2019·Nature Reviews. Rheumatology·Jun DengDi Yu
Jun 23, 2020·Chinese Medical Journal·Xi-Chen ZhaoFan-Jun Meng
Aug 23, 2019·Therapeutic Advances in Musculoskeletal Disease·Rahul BodkheVeena Taneja
Nov 28, 2019·Journal of Immunology Research·Huihui XuHongyan Zhao
Jun 6, 2019·Frontiers in Microbiology·Fiorella Sabrina BelforteAlberto Penas-Steinhardt
May 28, 2020·Frontiers in Immunology·Chunye Zhang, Ming Yang
Dec 15, 2020·Scientific Reports·Xiangsheng CaiXiaorong Yang
Mar 19, 2021·Pediatric Research·Yuying LiuJon Marc Rhoads
Aug 27, 2021·Frontiers in Molecular Biosciences·Jun ChenChun Loong Ho
Nov 16, 2019·Annals of the Rheumatic Diseases·Sergey MoiseevLidia Lysenko Kozlovskaya

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